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Step 1 - Elise > UWorld Day Seven > Flashcards

UWorld Day Seven Flashcards

1
Q

PDGF and TGF-beta

A

help control fibroblast migration and proliferation during wound healing

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2
Q

MOA of bisphosphonates (i.e. risedronate)

MOA of SERMs (i.e. raloxifene)

A

Bisphosphonates inhibits mature osteoclast-mediated bone resorption.

SERMs inhibit osteoclast differentiation.

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3
Q

MCC of death in TCA overdose

A

inhibit fast Na channels, leading to cardiac arrhythmias

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4
Q

V617F mutation in JAK2 gene where valine is replaced by a phenylalanine - what is the result?

A

renders hematopoetic stem cells more sensitive to growth factors, resulting in polycythemia vera.

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5
Q

water under the bridge

A

distal ureter passes inferolateral to the uterine artery prior to entering the bladder - ureter can be damaged during hysterectomy

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6
Q

pseudohyphae with blastoconidia

A

candida

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7
Q

agitation and spasms after being in a bat cave, progressing to coma. Dx and what kind of vaccine?

A

rabies

killed vaccine

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8
Q

type of study when participants are randomly allocated to 2 or more treatments consecutively.

A

crossover.

often contains a washout period.

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9
Q

“thunderclap HA” - Dx and MC complication

A

SAA
MC complication is secondary vasospasm 4-12 days after.

Give nimodipine (CaCB) to avoid

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10
Q

name of infarct of small penetrating deep vessels that supply the basal gnanglia and subcortical white matter (corona radiata and IC)

A

lacunar infarct

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11
Q 
where is the lesion:
pure motor hemiparesis
pure sensory stroke
ataxia-hemiplegia syndrome
dysarthria-clumsy hand syndrome
A

posterior limb of IC or basal pons
ventroposterolateral or ventroposteromedial thalamus
posteror limb of IC or basal pons
genu of IC or basal pons

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12
Q

TdT+ and PAS positive = ?

what if also CD19 and CD10+?
what if CD1, 2, 5+?

A

lymphoblast

B-cell precursor
T-cell prcursor

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13
Q

peroxidase positive granules

A

auer rods (AML)

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14
Q

HSP etiology

A

IgA immune complex vasculitis

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15
Q

Night-time pruritis + HSM

A

PBS

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16
Q

rose spots on turnk

A

salmonella typhi

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17
Q

sudden onset of blindness in one eye +/- polymyalgia rheumatica (pelvic girdle pain) +/- HA and jaw claudicaiton

A

temporal arteritis (giant cel vasculitis due to granuloma build up in media consitiing of neutrophils and macrophages)

18
Q

spike and dome on methanamine silver stain in kidney

A

membranous glomerulopathy

19
Q

AR Hardy Weinberg:

if the AR condition is very rare, then p=1 and carrier must be 2q

A

P(affected child given carrier parents) = 1/4
x [P(carrier mother) = 1 (bc mom already gave allele to first affected son)]
x [P (carrier father) = calculate using HW]

20
Q

in endothelial cells, what connects collagen to integrin?

A

fibronectin

21
Q

what is a true v. false diverticula?

A

false - only mucosa nad submucosal layers

22
Q

stress related mucosal damage caused by local ischemia in setting of physiological stress (shock, extensive burns, sepsis, severe trauma)…

  • in setting of severe trauma/burns
  • from intracranial injury, causing direct vagal stimulation
A

Curling ulcers

cushing ulcers

23
Q

Part of brain responsible for executive function and personality.

  • what specific location if apathetic an depressed?
  • what specific location if disinhibited behavior
A

frontal lobe

  • left
  • right side
24
Q

part of brain responsible for visual auditory and motor signals.

A

parietal lobe

25
Q

part of brain responsible for language, sensory, memory, and hyperorality/sexuality

A

temporal

26
Q

most potent leukotriene chemotactic

A

LTB4

27
Q

what nerve?
anterior hip dislocation

decr thigh adduction

L2-4

A

Obturator nerve

28
Q

what nerve?
pelvic fracture or mass involving iliopsoas/iliacus (hematoma or abscess)

imparied felxion of thigh and extension of leg

loss of sensation over knee and medial lower leg

L2-4

A

femoral nerve

29
Q

what nerve?
fubula neck fracture or nerve compression at fibular neck,

decreased food eversion, dorsiflexion, toe extension

loss of sensation over dorsum of foot

L4-S2

A

common peroneal nerve

30
Q

what nerve?
trauma to knee

loss of foot inversion, plantar flexion, toe extension

loss of sensation over underside of food

L4-S3

A

tibial nerve

31
Q

what nerves?

  1. L4-S1, thigh abduction
  2. L5-S2, thigh extension
A
  1. superior gluteal nerve

2. inferior gluteal nerve

32
Q

unvax child - rash starts on face and moves down to trunk - what two options?
A) if baby has LAD
B) if baby has preceding sickness

A

rubella

measles (rubeola)

33
Q

S1

A

achilles reflex

34
Q

L4

A

patellar reflex

35
Q

Waht adds TTAGGG to the 3’ end of chromosomes?

A

telomerase

36
Q

what is sheehan syndrome?

what do they often present with?

A

high estrogen levels durin gpregnancy lead to enlargement of pituitary without increased blood supply. peripartum hypotension can cause ischemic necrosis of the pituitary leading to panhypopituitarism (Sheenhan)

often present with failure of lactation

37
Q

severe hypoxemia and bilateral pulmonary infiltrates in absence of evidence of pulmonary edema. PO2/FiO2

A

ARDS

38
Q

dopamine antagonist in CNS and PNS

A

clozapine - antipsychotic

39
Q

anxiolytic class

A

benzodiazepine

40
Q

serotonin and norepinepherine reuptake inhibitor that esp blocks also Histamine, alpha, and muscarinic, resulting in AE of orthostatic hypotension, anticholinergic, reflex tachycardia

A

TCA - i.e. amitryptaline

*CI in suicidal patients

41
Q

what is sertraline?

A

a SSRI - Selective Serotonin Reuptake Inhibitor

42
Q

reactivation TB is an example of what HSR?

A

type 4 HSR

Step 1 - Elise (30 decks)

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