Genetics

Question 1

L-myc

Answer 1

Small Cell/Oat Cell Lung Cancer

amplification, nuclear regulatory protein

Question 2

N-myc

Answer 2

neurblastoma

amplification, nuclear regulatory protein

Question 3

t(8;14)

Answer 3

C-myc; Burkitt Lymphoma
translocation
translocation, nuclear regulatory protein

Question 4

t(9;22)

Answer 4

Chronic Myelogenous Leukemia
abl-bcr
translocation

Question 5

cdk4 assciated with ___ cancers

Answer 5

malignant melanoma and glioblastoma multiforme

Question 6

function of CDK4 kinase

Answer 6

binds to cyclin D1 to phorphorylate Rb gene product. (hyperphosphorylation = inhibits function

Question 7

erb-2

Answer 7

breast, ovary, stomach
Gene product - EGFR
Amplification

Question 8

ret

Answer 8

medullary thyroid carcinoma (think MEN2a and 2b

point mutation

Question 9

Ki-ras

Answer 9

lung, pancreas, colon

GTP binding protein

Question 10

erb-B1 and erb-B3

Answer 10

erb-B1 - SCC of lung, EGFR, overexpression

erb-B3 - breast, EGFR, overespression

Question 11

sis

Answer 11

astrocytoma

platelet derived growth factor,
overexpression

Question 12

CDH1

Answer 12

encodes E-cadherin,

high risk of gastric adenocarcinoma and infiltrating lobular carcinoma