DIT Quizzes Flashcards
Embryologic origin of:
- ant pit and lens
- post pit and retina
- sclera
- mammary glands, parotid glands, sweat glands)
- post pit and retina: neural tube
- sclera: notochord
- mammary glands, parotid glands, sweat glands, ant pit and lens: surface ectoderm
Developmental age of 4 chambered heart.
Week 4
Developmental age of genitalia with sex-specific characteristics.
Week 10
Developmental age of fetal movement.
Week 8
Developmental age of limb buds.
Week 4
Aminoglycosides, fluoroquinolones, and tetracyclines - all have what in common?
Potentially teratogenic antibiotics
A pregnant woman dx w/ DVT. What anticoagulant is contraindicated in pregnancy. What is preferred.
CI is warfarin
Preferred is heparin
Exam of fetus from SAB at 14 weeks gestation reveals vestigial pair of legs that arises from torso just below the arms. A mutation in what family of genes is most likely the cause of this malformation?
HOX (appendage layout)
SHH - ant-to-post/ cranial-to-caudal
(Wnt-7 - dorsal-to-ventral)
(Fibroblast Growth Factor - limb elongation)
Nuclear localization signal must be present for what? What are the aa?
Must be present on a protein to gain entry into nucleus. Amino acids are proline, arginine, lysine.
What cyclin-CDK complex assists progression from G1-to-S phase.
CDK4 - D-Cyclin
CDK2 - E-Cyclin
What cyclin-CDK complex assists progression from G2-to-M phase.
CDK1 - B-Cyclin
CDK2 - A-Cyclin
Name the molecule that the golgi adds to proteins to direct proteins to the lysosomes
Mannose-6-Phosphate
The three methods to break down proteins.
- proteasomal (ubiquetin)
- Lysosomal
- Ca-dependent enzymes
Drugs that act on mictrotubules
Vinca alkyloids
Benzimidazoles (worms)
Griseofulvin
Colchicene
Vincristine and vinblastine - MoA
v.
Paclitaxel and docetaxel MoA
prevent polymerization (growth) of microtubules hyperstabilization microtubules - cannot pull apart
