UTI STI drugs Kinder

Question 1

what drug class is amoxicillin

Answer 1

beta lactam

Question 2

amoxicillin is drug choice for what bacteria

Answer 2

enterococci

Question 3

drugs of choice for Tx of uncomplicated cystitis

Answer 3

TMP.SMX
nitrofurantoin
fosfomycin

Question 4

MOA TMP SMX

Answer 4

inhibits folic acid synthesis in bacteria
SMX- dihydropteroate synthestase
TMP- dihydrofolate reductase

Question 5

MOA nitrofurantoin

Answer 5

drug reduced, damage DNA

Question 6

MOA fosfomycin

Answer 6

inhibits early stage cell wall synthesis

decreased formation N acetylmuramic acid

Question 7

drug of choice for klebsiella

Answer 7

TMP SMX

Question 8

most common microbe in uncomplicated bladder infections

Answer 8

1- e coli

2- saprophyticus

Question 9

Tx for saprophyticus

Answer 9

1st generation cephalosporin or TMP SMX

Question 10

Tx e coli cystitis

Answer 10

TMP sMX

Question 11

Tx proteus mirabilis cystitis

Answer 11

TMP SMS

Question 12

Tx enterococcus cystitis

Answer 12

ampicillin amoxicillin

Question 13

rule out what in cystitis

Answer 13

pyelonephritis

Question 14

when do you decide not to use TMP SMX for e coli infection

Answer 14

if >20% Resistant

Question 15

what to use if E coli R cystitis

Answer 15

ciprofloxacin

Question 16

what antibiotics can increase warfarin INR

Answer 16

TMP SMX– inhibits CYP2C9

Question 17

what antibiotics can enhance anticoagulant effect warfarin

Answer 17

amoxicillin

azithromycin

Question 18

Vit K dependent coagulation factors

Answer 18

2 7 9 10 and protein C and S

Question 19

how does warfarin work

Answer 19

depletes vit K stores so depletes the vit K dependent factors

Question 20

which warfarin is more potent

Answer 20

S warfarin- CYP2C9

Question 21

recurrent UTI definition

Answer 21

> 2 in 6 mo or >3 in 1 year

Question 22

risk factors for multidrug R organisms

Answer 22

hospitalization in last 6 mo
urinary catheter
nursing home resident

Question 23

what organisms do you worry about for multidrug R urine bacteria

Answer 23

pseudomonas and enterococci

Question 24

in patient Tx pyelonephritis

Answer 24

IV
fluroquinolones
aminoglycoside +/- ampicillin
extended spectrum cephalosprin or sextended spectrum penicillin +/- aminoglycoside
carbapenem--- multidrug R

Question 25

how does ciprofloxacin work

Answer 25

targets DNA gyrase and topoisomerase IV

Question 26

what drug can interact with cipro

Answer 26

divalent/trivalent cations impair absorption

e.g. Ca carbonate

Question 27

macrolides work where

Answer 27

50 s ribosomes inhibiting protein synthesis

Question 28

MOA aminoglycosides and tetracyclines

Answer 28

30 s

Question 29

main adverse drug reaction azithromycin

Answer 29

nausea