UTI STI drugs Kinder Flashcards
what drug class is amoxicillin
beta lactam
amoxicillin is drug choice for what bacteria
enterococci
drugs of choice for Tx of uncomplicated cystitis
TMP.SMX
nitrofurantoin
fosfomycin
MOA TMP SMX
inhibits folic acid synthesis in bacteria
SMX- dihydropteroate synthestase
TMP- dihydrofolate reductase
MOA nitrofurantoin
drug reduced, damage DNA
MOA fosfomycin
inhibits early stage cell wall synthesis
decreased formation N acetylmuramic acid
drug of choice for klebsiella
TMP SMX
most common microbe in uncomplicated bladder infections
1- e coli
2- saprophyticus
Tx for saprophyticus
1st generation cephalosporin or TMP SMX
Tx e coli cystitis
TMP sMX
Tx proteus mirabilis cystitis
TMP SMS
Tx enterococcus cystitis
ampicillin amoxicillin
rule out what in cystitis
pyelonephritis
when do you decide not to use TMP SMX for e coli infection
if >20% Resistant
what to use if E coli R cystitis
ciprofloxacin
what antibiotics can increase warfarin INR
TMP SMX– inhibits CYP2C9
what antibiotics can enhance anticoagulant effect warfarin
amoxicillin
azithromycin
Vit K dependent coagulation factors
2 7 9 10 and protein C and S
how does warfarin work
depletes vit K stores so depletes the vit K dependent factors
which warfarin is more potent
S warfarin- CYP2C9
recurrent UTI definition
> 2 in 6 mo or >3 in 1 year
risk factors for multidrug R organisms
hospitalization in last 6 mo
urinary catheter
nursing home resident
what organisms do you worry about for multidrug R urine bacteria
pseudomonas and enterococci
in patient Tx pyelonephritis
IV fluroquinolones aminoglycoside +/- ampicillin extended spectrum cephalosprin or sextended spectrum penicillin +/- aminoglycoside carbapenem--- multidrug R
