Male phys- montemayor

Question 1

low total testosterone
high LH and FSH
semen volume and [ ] low
explain high FSH LH

Answer 1

because feedback from low testosterone

Question 2

47 XXY

Answer 2

klinefelters

Question 3

most common Sx klinefelters

Answer 3

infertility and gynecomastia

Question 4

most common genetic form of male hypogonadism

Answer 4

klinefelters

Question 5

sex determining region on Y chromosome

Answer 5

SRYtranscription factor (testis determining factor

Question 6

what hormone prevents the mullerian ducts from progressing

Answer 6

AMH

anti-mullerian hormone

Question 7

what is required for development of seminal vesicles, ejaculatory duct and vas deferens

Answer 7

testosterone

Question 8

what cells produce tesosterone

Answer 8

leydig cells

Question 9

which hormone stimulates fetal leydig cell production of testosterone during development prior to fetal pituitary LH

Answer 9

hCG

Question 10

required for development penis scrotum and prostate

Answer 10

DHT

dhydrotestosterone

Question 11

which has highger affinity for Testosterone R

Answer 11

DHT

Question 12

what enzyme is required for conversion testosterone- DHT

Answer 12

5 alpha reductase 2

Question 13

what produces AMH

Answer 13

sertoli cells

Question 14

what promotes development of gynecomastia

Answer 14

presence of E
increased E:T ratio
peripheral conversion T to E via CYP 19 aromatase

Question 15

what hormone normally initiates puberty

Answer 15

pulsatile GnRH

Question 16

what are gonadotropin levels in primary hypogonadism

Answer 16

elevated

androgen decreased

Question 17

major actions of andorgens

Answer 17

wolffian structures
erythropoietin synthesis
bone growth
libido
etc..

Question 18

which form is most circulating T found

Answer 18

SHBG
serum albumin
least amount is free

Question 19

what protein maintains T [ ] in testes

Answer 19

ABP androgen binding protein

Question 20

why is it important for T to be concentrated in testes

Answer 20

needs to be at least 100x circulating levels to promote spermatogenesis

Question 21

What promotes secretion of LH and LSH

Answer 21

low hormone levels ( E and T)

pulsatile GnRH

Question 22

FSH works on what cells

Answer 22

sertoli

Question 23

LH works on what cells

Answer 23

leydig

Question 24

Why would continuous GnRH be a Tx for prostate CA

Answer 24

constant GnRH dec LH and FSH

so dec T

Question 25

key functions of sertoli cells

Answer 25

``` produce aromatase maintain blood testis barrier R for hormones produce ABP produce AMH ```

Question 26

3 key hormones promote adequate spermatogenesis in normal male

Answer 26

high T FSH LH

Question 27

GH affects spermatogenesis how

Answer 27

early division of sperm

Question 28

what Tx could you use for klinefelter Syndrome

Answer 28

androgen replacement therapy

Question 29

likely effect of giving exogenous T to klinefelter male

Answer 29

virilization of secondary male sexual traits

Question 30

can exogenous T of klinefelters male promote fertility?

Answer 30

no | seminiferous tubule likely is destroyed

Question 31

failure of testes to descend impairs what aspect of repro function

Answer 31

maturation of spermatogonia because of temperature differene

Question 32

dec in facial and axillary hair and dec penile length and hypogonadism deficiency in what androgen explains findings

Answer 32

DHT

Question 33

generate Ab that bind and neutralize FSH bioactivity | expected to have a feedback decrease in what

Answer 33

decreased serum inhibin B levels

Question 34

sertoli cells normally do what in seminiferous tubules

Answer 34

maintain blood testis barrier