Amenorrhea and endometriosis/infertility Flashcards

1
Q

labs to order for primary amenorrhea

A
serum pregnancy test
CBC
US
FSH/LH
E2
karyotype
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2
Q

whats telarche

A

onset of female breast development

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3
Q

what is pubarche

A

appearance of sexual hair

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4
Q

what is adrenarch

A

growth of axillary hair

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5
Q

what is primary amenorrhea

A

failure to menstruate by age 16

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6
Q

what is secondary amenorrhea

A

absence of menstruation for 3 cycles> 6 mo

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7
Q

common causes primary amenorrhea

A
constitutional delay
45XO, 46XY
pituitary tumor
congenital adrenal hyperplasia
genital tract anomaly
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8
Q

signs pituitary tumor

A

headaches, blurry vision

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9
Q

Dx steps primary amenorrhea

A
height weight BP
evaluate secondary sexual characteristics
look for signs androgen excess
visual fields
chromosomes
FSH LH E2
androgens TSH and PRL
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10
Q

common causes secondary ammenorrhea

A
stress
weight loss/gain
post pill and depo provera
PCOS
premature menopause or premature ovarian failure
hyperPRL
pituitary adenoma
drug induced
PREGNANCY
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11
Q

what is sheehans

A

post partum hemorrhage, infarct pituitary

stop menstruating

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12
Q

uncommon causes secondary amenorrhea

A
kallmans
sheehans
cushings
ashermans
thyroid disease
post encephalitis
androgen producing tumors
cervical stenosis
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13
Q

clincal evaluation for secondary amenorrhea

A

life events, weight exercise, pregnancy

visual fields, secondary sexual characteristics

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14
Q

primary labs for secondary amenorrhea

A

FSH LH E2 TSH PRL
androgens
US
visual fields

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15
Q

secondary tests secondary amenorrhea

A

CT pituitary
DXM suppression
hydroxyPROG
hysteroscopy

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16
Q

labs for primary infertility

A

FSH LH Progesterone, semen analysis
HSG
diagnostic laparoscopy

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17
Q

when is progesterone done

A

day 21

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18
Q

hemosiderin laden macrophages in spots found on ligaments on uterus

A

endometriosis

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19
Q

endometriosis

A

ectopic endometrium

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20
Q

how to Dx endometriosis

A

laparoscopy +/- Bx

21
Q

Sx endometriosis

A

dysmenorrhea
dyspareunia
infertility

pre-menstrual staining
pain with defection during menstruation
intermenstrual pain
disordered cycles

22
Q

most important in Dx of endometriosis

A

careful Hx

23
Q

gold standard for endometriosis Dx

A

laparoscopy

24
Q

differenctial Dx for endometriosis

A

primary dysmenorrhea
IBS
ovulation pain
PID

25
Q

theories that cause endometrium

A

retrograde menstruation

peritoneal metaplasia

26
Q

predisposing factors endometriosis

A
familial
disordered immunity
environmental toxins
recurrent ovulation
infertile partner
obstructed menstrual flow
27
Q

hwo to mange endometriosis

A

if pain use medical Rx
if infertility then surgery
no problem, don’t need to tx

28
Q

what type of medical Rx would you use in endometriosis

A

progestins: OCP, provera or norethisterone, mirena IUD

29
Q

benefits of laparoscopy with diathermy in endometriosis

A

dec pain

dec infertility

30
Q

what is infertility

A

12 mo of regular sex without contraception

31
Q

principal causes of infertility

A
ovulation
sperm
tubal
cervical factor
endometriosis
32
Q

how to test ovulation

A

check body temperature- progesterone
check progesterone at day 21
LH surge in urine

33
Q

how to test if tubes are still open

A

hysterosalpingogram
laparoscopy with dye studies
(both can open tube up if mild obstructin)

34
Q

testing cervix

A

around day 12 or 13
sample mucous after intercourse
can also use this to look at sperm

35
Q

what is semen analysis

A
48-72 hours
collect whole sample
examined 1-2 hours at room temp
look at count, motility and morphology
if abnormal- repeat.
36
Q

labs if suspec tmenopause

A
CBC
FSH LH
TSH
Pregnancy
endometrial Bx and pap
37
Q

Tx for menopause with Sx

A

HRT

38
Q

perimenopause

A

time leading up to menopause, time when ocarian function and hormone production are declining

39
Q

premature menopause

A

before age 40

40
Q

menopause Sx

A
vasomotor Sx
sleep changes
mood changes
UG Sx, dryness and atrophy
sexual well being, libido
skin changes
41
Q

decreased E can lead to

A

vasomotor Sx, urogenital disorders, CHD risk factors, skin changes
CV disease
bone loss/osteoporosis

42
Q

decreased P can cause

A

irregular periods

PMS

43
Q

decreased androgen Sx

A

decrease mood, energy
msucle weakness
dec libido
osteopenia

44
Q

what is better HT at time of menopause or after menopause

A

HT does not increase CHD if started within 5 years of onset

does increase risk CHD if initiated late

45
Q

when is risk of VTE with HT occur

A

1st year of use

46
Q

When should E be taken to prevent dementia of menopause

A

perimenopause or very onset menopause

47
Q

when do we give P as well as E for HRT

A

still have uterus because protects against uterine CA

48
Q

Tx for menopausal patients with mild vasomotor Sx

A

lifestyle changes
dietary isoflavones
black cohosh
Vit E

49
Q

Tx for mod-severe vasomotor Sx

A

HT “gold standard”
SSRIs and gabapentin
Progestogens