Martin, drugs for male GU

Question 1

What drugs are used for BPH

Answer 1

5a-reductase inhibitors
alpha adrenergic antagonists
saw palmetto

Question 2

what drugs are used for ED

Answer 2

PDE 5 inhibitors

alprostadil

Question 3

what are the 5alpha reductase inhibitors

Answer 3

finasteride and durasteride

Question 4

what are the alpha adrenergic antagonists

Answer 4

prozosin
terzosin
doxazosin
alfuzosin
tamsulosin
silodosin

Question 5

what are the PDE 5 inhibitors

Answer 5

sildenafil(viagra)
tadalafil
vardenafil
avanafil

Question 6

MOA 5 alpha reductase inhibitor

Answer 6

inhibition 5a reductase reduces levels of dihydrotestosterone within 8 hours

Question 7

adverse effects 5 alpha reductase inhibitors

Answer 7

impotence and decreased libido

Question 8

which 5 alpha reductase inhibitor preferentially antagonizes type II 5 alpha reductase

Answer 8

finasteride

Question 9

finasteride also approved to Tx what

Answer 9

male pattern baldness

hirsutism in women

Question 10

what drug has a longer half life than finasteride

Answer 10

dutasteride

Question 11

clinical manifestations of BPH

Answer 11

increased frequency of urination, nocturia, hesitancy, urgency and weak urinary system

Question 12

when does tx start for BPH

Answer 12

Sx have significant impact on patients life

Question 13

alpha adrenergic antagonists are used to Tx what

Answer 13

pheochromocytoma, primary HTN, BPH, Ischemic HD, arrhythmias, endocrinologic and neurologic disorders and glaucoma

Question 14

most common cause ED

Answer 14

atherosclerosis

Question 15

what R mediate smooth muscle tone in prostate

Answer 15

alpha 1

Question 16

what are the long acting alpha adrenergic antagonists

Answer 16

everyone EXCEPT prazosin

Question 17

which alpha antagonist has more CV side effects

Answer 17

prazosin

Question 18

adverse effects prazosin

Answer 18

palpitations and orthostatic hypotension/syncope

Question 19

common drugs that alter sexual response

Answer 19

SSRIs antidepressants
spironolactone and thiazide diuretics
antipsychotics-phenothiazines
benzodiazepines, alcohol, cocaine, marijuana, hallucinogens
nonselective beta blockers
centrally-acting sympatholytics

Question 20

which alpha antagonist is selcetive for a1A and a1D

Answer 20

tamsulosin

Question 21

adverse effect tamsulosin

Answer 21

abnormal ejaculation

Question 22

MOA saw palmeto

Answer 22

inhibits 5 alpha reductase I and II and inhibits dihydrotestosterone binding to androgen R

Question 23

saw palmetto is better for what stage BPH

Answer 23

mild to moderate

Question 24

MOA PDE 5 inhibitors

Answer 24

selective inhibition of PDE-5 increase intracavernosal cGMP levels and causes relaxation of the nonvascular smooth muscle of corpora cavernosa

Question 25

which PDE5 inhibitor has effects that can last 36 hrs

Answer 25

tadalafil

Question 26

drug interactions with PDE5 inhibitors

Answer 26

use with nitrates can lead to severe hypotension and syncope

Question 27

adverse effects PDE 5 inhibitors

Answer 27

visual changes and hearing loss

Question 28

will PDE5 inhibitors work in men with loss of potency due to a cord injury

Answer 28

no

Question 29

why does an erection require relaxation of nonvascular smooth muscle

Answer 29

permits inflow of blood which P causes the erection

Question 30

what is alprostadil

Answer 30

PG E1 analog that relaxes trabecular smooth muscle by dilating cavernosal aa

Question 31

alprostadil is used in who

Answer 31

those who don't respond to PDE -5 inhibitors

Question 32

adverse effect alprostadil

Answer 32

penile pain

Question 33

how long does alprostadil work

Answer 33

up to 1 hour

Question 34

which PDE 5 inhibitors do you take an hour before sexual activity

Answer 34

sildenafil and vardenafil

Question 35

which PDE 5 inhbiitor is available for daily use

Answer 35

tadalafil

Question 36

which PDE 5 inhibitor do you take 30 min before sexual activity

Answer 36

tadalafil and avanafil

Question 37

high fat meals delay absorption of what PDE 5 inhibitors

Answer 37

vardenafil and sildenafil

Question 38

"blue vision"

Answer 38

sildenafil

Question 39

common side effects PDE 5 inhibitors

Answer 39

flushing, HA and dyspepsia

Question 40

what metabolizes PDE 5 inhbiitors

Answer 40

CYP 450 3A4

Question 41

what type of drug will worsen Sx of BPH

Answer 41

cholinergic antagonist like oxybutyn

Question 42

role 5 alpha reductase

Answer 42

testosterone to dihydrotestosteron

Question 43

what drug is used for urinary incontinence

Answer 43

atropine | muscarinic acetylcholine antagonist

Question 44

alpha1A main role

Answer 44

vasoconstriction and BP | vascular smooth muscle