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Year2 Repro exam II > Martin, drugs for male GU > Flashcards

Martin, drugs for male GU Flashcards

1
Q

What drugs are used for BPH

A

5a-reductase inhibitors
alpha adrenergic antagonists
saw palmetto

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2
Q

what drugs are used for ED

A

PDE 5 inhibitors

alprostadil

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3
Q

what are the 5alpha reductase inhibitors

A

finasteride and durasteride

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4
Q

what are the alpha adrenergic antagonists

A 
prozosin
terzosin
doxazosin
alfuzosin
tamsulosin
silodosin
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5
Q

what are the PDE 5 inhibitors

A

sildenafil(viagra)
tadalafil
vardenafil
avanafil

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6
Q

MOA 5 alpha reductase inhibitor

A

inhibition 5a reductase reduces levels of dihydrotestosterone within 8 hours

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7
Q

adverse effects 5 alpha reductase inhibitors

A

impotence and decreased libido

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8
Q

which 5 alpha reductase inhibitor preferentially antagonizes type II 5 alpha reductase

A

finasteride

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9
Q

finasteride also approved to Tx what

A

male pattern baldness

hirsutism in women

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10
Q

what drug has a longer half life than finasteride

A

dutasteride

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11
Q

clinical manifestations of BPH

A

increased frequency of urination, nocturia, hesitancy, urgency and weak urinary system

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12
Q

when does tx start for BPH

A

Sx have significant impact on patients life

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13
Q

alpha adrenergic antagonists are used to Tx what

A

pheochromocytoma, primary HTN, BPH, Ischemic HD, arrhythmias, endocrinologic and neurologic disorders and glaucoma

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14
Q

most common cause ED

A

atherosclerosis

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15
Q

what R mediate smooth muscle tone in prostate

A

alpha 1

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16
Q

what are the long acting alpha adrenergic antagonists

A

everyone EXCEPT prazosin

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17
Q

which alpha antagonist has more CV side effects

A

prazosin

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18
Q

adverse effects prazosin

A

palpitations and orthostatic hypotension/syncope

19
Q

common drugs that alter sexual response

A 
SSRIs antidepressants
spironolactone and thiazide diuretics
antipsychotics-phenothiazines
benzodiazepines, alcohol, cocaine, marijuana, hallucinogens
nonselective beta blockers
centrally-acting sympatholytics
20
Q

which alpha antagonist is selcetive for a1A and a1D

A

tamsulosin

21
Q

adverse effect tamsulosin

A

abnormal ejaculation

22
Q

MOA saw palmeto

A

inhibits 5 alpha reductase I and II and inhibits dihydrotestosterone binding to androgen R

23
Q

saw palmetto is better for what stage BPH

A

mild to moderate

24
Q

MOA PDE 5 inhibitors

A

selective inhibition of PDE-5 increase intracavernosal cGMP levels and causes relaxation of the nonvascular smooth muscle of corpora cavernosa

25
Q

which PDE5 inhibitor has effects that can last 36 hrs

A

tadalafil

26
Q

drug interactions with PDE5 inhibitors

A

use with nitrates can lead to severe hypotension and syncope

27
Q

adverse effects PDE 5 inhibitors

A

visual changes and hearing loss

28
Q

will PDE5 inhibitors work in men with loss of potency due to a cord injury

A

no

29
Q

why does an erection require relaxation of nonvascular smooth muscle

A

permits inflow of blood which P causes the erection

30
Q

what is alprostadil

A

PG E1 analog that relaxes trabecular smooth muscle by dilating cavernosal aa

31
Q

alprostadil is used in who

A

those who don’t respond to PDE -5 inhibitors

32
Q

adverse effect alprostadil

A

penile pain

33
Q

how long does alprostadil work

A

up to 1 hour

34
Q

which PDE 5 inhibitors do you take an hour before sexual activity

A

sildenafil and vardenafil

35
Q

which PDE 5 inhbiitor is available for daily use

A

tadalafil

36
Q

which PDE 5 inhibitor do you take 30 min before sexual activity

A

tadalafil and avanafil

37
Q

high fat meals delay absorption of what PDE 5 inhibitors

A

vardenafil and sildenafil

38
Q

“blue vision”

A

sildenafil

39
Q

common side effects PDE 5 inhibitors

A

flushing, HA and dyspepsia

40
Q

what metabolizes PDE 5 inhbiitors

A

CYP 450 3A4

41
Q

what type of drug will worsen Sx of BPH

A

cholinergic antagonist like oxybutyn

42
Q

role 5 alpha reductase

A

testosterone to dihydrotestosteron

43
Q

what drug is used for urinary incontinence

A

atropine

muscarinic acetylcholine antagonist

44
Q

alpha1A main role

A

vasoconstriction and BP

vascular smooth muscle

Year2 Repro exam II (19 decks)

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