Uterine Tumors

Question 1

Epidemiology of uterine cancer

Answer 1

• most common pelvic tumor in developed countries
• 5x more prevalent than cervical cancer

Question 2

Etiology of uterine cancer

Answer 2

Endometrial carcinoma:
1. endometriod: hyperestrogenism, obesity, hypertension, diabetes mellitus
2. serous: endometrial atrophy with agressive postmenopausal bleeding

Question 3

Histology of uterine cancer

Answer 3

• abnormally arranged endometrial gland
• serous: psammoma bodies
• G-grading: 1-3
• FIGO classification

Question 4

Symptoms of uterine cancer

Answer 4

abnormal/postmenopausal uterine bleeding

Question 5

Diagnosis of uterine cancer

Answer 5

• hysteoscopy
• MRI (mymetrium and pelvic lymph nodes)
• CT (paraaortic)

Question 6

Radiation therapy for uterine cancer

Answer 6

• postoperative radiation therapy is most common
• vaginal brachytherapy for G3
• preop. RT for poor diagnosis
• definitive RT

Question 7

Surgical therapy for uterine cancer

Answer 7

• surgery is most important
• ovaries may be spared but fallopian tubes must be resected

Question 8

Pharmacological therapy for uterine cancer

Answer 8

• surgery first
• if disseminated: neadjuvant chemotherapy
• if inoperable: progesterone
• targeted immunotherapy