Cervical Tumors Flashcards
1
Q
Epidemiology of cervical cancer
A
- higher risk for 30-39 yrs and above 70 yrs
- decreased risk in developing countries
- high risk in case of HPV
2
Q
Etiology of cervical cancer
A
- HPV 16, 18, 31, 33
- viral proteins E6 (p53) and E7 (Rb)
- HPV vaccine
3
Q
Histology of cervical cancer
A
- SCC: 80-90%
- AC: 5-8%
- Sarcoma, melanoma
- NET (neuroendocrine tumor): 1-3%
4
Q
Symptoms of cervical cancer
A
- postcoital or postmenopausal bleeding
- watery vaginal discharge
- advanced disease: weight loss, bleeding, ureteric obstruction, pain, anemia
5
Q
Diagnosis of cervical cancer
A
- DRE
- imaging: CT, MRI, PET/CT
- cervical smear
- colposcolpy
- cystoscopy
6
Q
Radiation therapy for cervical cancer
A
- good sensitivity
- acute SE
- teletherapy and HDR brachytherapy
- EBRT
- can be combined with cisplatin
7
Q
Surgical therapy for cervical cancer
A
- Ia: surgery
- Ib2-IV: RT
- IV: surgery + chemotherapy
- diagnostic surgery: conization
- radical surgery: Wetheim’s hystorectomy
8
Q
Pharmacological therapy for cervical cancer
A
- combined chemotherapy: cisplatin + paclitacel + bevacizumab
- neadjuvant
chemotherapy as radiosensitizer
