Pancreatic Tumors Flashcards
1
Q
Epidemiology of pancreatic cancer
A
- 7th deadliest cancer for both sexes
- highest incidence in developed countries
1
Q
Etiology of pancreatic cancer
A
- smoking
- diabetes mellitus
- cirrhosis
- pancreatitis
- hight fatty food
- obesity
2
Q
Histology of pancreatic cancer
A
- most common is exocrine adenocarcinoma
- neuroendocrine carcinoma is common
- rarely endocrine (ie. insulinoma)
3
Q
Symptoms of pancreatic cancer
A
- strong belt-like pain radiating to the back
- gall bladder obstruction
- jaundice
- weight loss
- dark urine
- steatorrhea
- Curvoisier’s sign: jaudice with enlarged gall bladder but no pain
4
Q
Diagnosis of pancreatic cancer
A
- ERCP: endoscopic retrograde cholangiopancreatography
- endoscopic US
- abdominal US
- CT
5
Q
Radiation therapy for pancreatic cancer
A
- most common: postop. w/ chemo
- postop: chemo (45-50 Gy)
- chemoradiotherapy is better that chemotherapy alone
- SBRT: 6wks, high accuracy, hypofractionated, high doses (<5cm)
6
Q
Surgical therapy for pancreatic cancer
A
- preferred method (20%), often unresectable
- radical surgery
7
Q
Pharmacological therapy for pancreatic cancer
A
- 80-90% treated w/ chemotherapy
- postoperative: gemcitabine + capecitabine
- locally advanced/metastatic: FOLFIRINOX
8
Q
What is FOLFIRINOX?
A
- folinic acid
- 5-FU
- irinotecan
- oxaliplatin
