Soft Tissue Tumors Flashcards
1
Q
Epidemiology of soft tissue cancer
A
- incidence: 2-5 per 100,000
- mortality: 1-3 per 100,000
- any age group
- benign:malignant = 100:1
2
Q
Etiology of soft tissue cancer
A
- genetic: gardener syndrome
- environmental: chlorophenols
- RT
- chronic lymphoedema
- HSV (Kaposi sarcoma)
3
Q
Histology of soft tissue cancer
A
about 80 histology entities
- fatty tissue
- fibroblastic
- myogenic
- periciter
- vascular
- nerve sheath
- GI stromal tumor
4
Q
Symptoms of soft tissue cancer
A
- palpable lump
- characteristically >5cm
- painful
- grows rapidly
- below superficial fascia
5
Q
Diagnosis of soft tissue tumors
A
imaging: CT, MRI, FDG-PET, US
- 65% extremity and torso
- 15% retroperitoneal
- 10% head and neck
6
Q
Radiation therapy for soft tissue cancer
A
- to spare limbs
- pre- or post-op.
- IMRT
- brachytherapy
- Ewing’s sarcoma + rhabdomiyosarcoma are radiosensitive
7
Q
Surgical therapy for soft tissue cancer
A
- aim is R0 resection
- limb sparing surgery
- postop. chemo is often combined
8
Q
Pharmacological therapy for soft tissue cancer
A
monotherapy:
- doxorubicin
- ifosfamide
combined therapy:
- CYVADIC scheme
- MAID scheme
- VIP (vepesin, ifosfamide, cisplatin)
- angiosarcoma: taxanes + gemcitabine
- leiomyosarcomas: gemcitabine (second/third line chemo: dacarbazine)
- brain/uterine: temzolomide
- peripheral nerve sheath tumors: etoposide + carboplatin
