Uterine Pathology Flashcards
• BENIGN muscular tumors aka: myomas, fibromyomas & fibroids
• M/C SOLID mass occurring during pregnancy
• Occur 20% white, & 50% black women older than 30 yrs
• Usually multiple & can occur anywhere in UT (m/c) or in CX or broad ligament
• Degeneration occurs when mass outgrows blood supply
• Usually NO clinical symptoms, but if present they include:
▪ Heavy periods, enlarged UT, pelvic pain due to degeneration, torsion or infection
• Sono: appearance varies
▪ Well circumscribed, HYPO masses w/ ↑ attenuation in mass, or calcifications
▪ Distortion of UT contour or compression of posterior bladder wall
• Rarely can become Malignant- clue is rapid growth in postmenopausal women
Leiomyomas (Fibroids)
arise from stalk
pedunculate
outside the uterus
exophytic
with in the myometrium
intramural
directly beneath the endo frequently projecting into UT cavity produces symptoms
Submucosal
lying close to outer peritoneal surface of uterus
Subserous
with in the broad ligament
Interligamentous
- BENIGN diffuse infiltration of endometrial glands & stroma into myometrium (usually extensive on POSTERIOR wall)
- Suspected in 40-50 yr w/ painful & irregular bleeding
- Sono: ↑ UT w/ normal contour, areas of ↓ echogenicity in myometrium w/ possible cysts & posterior myometrium thickening
Adenomyosis
- Found in CX due to obstructed & dilated endocervical glands
- Sono: sm., anechoic structures w/ post. acoustic enhancement
Nabothian cysts
• M/C type of GYN malignancy, w/ 75-80% in postmenopausal women who present w/ bleeding
• Risk factors include:
▪ Obesity & anovulatory cycles in PRE-menopausal women
▪ Postmenopausal women on estrogen therapy or TAMOXIFEN
▪ Family history of UT cancer or atypical hyperplasia
• Tumor mass grow into myometrium & can spread to CX, OV fallopian tubes & adnexa. If lymphatic infiltrated, can cause distant metastases.
• Clinical signs: postmenopausal bleeding, HYPERmenorrhea (in pt. still having periods) & PAIN
• Sono: ↑ UT size, altered shape & echotexture, inhomogeneous & thickened endo > 5 mm & fluid in endo cavity
Endometrial carcinoma
• Proliferation of endometrial glandular tissue
• 25% of atypical hyperplasia progresses to endo CA
• Common cause of abnormal bleeding in PERI & POST meno women
• Causes include:
▪ Unopposed estrogen HRT
▪ PCOD, obesity, estrogen producing tumors, & persistent anovulatory cycles
• Clinical signs similar to endo CA therefore do D&C for diagnosis
• Sono: should be done immediately post menstrual
▪ Homogeneous texture w/ possible cystic chg., smooth borders
▪ PREmenopausal women endo > 14 mm
▪ Postmenopausal women endo up to 8 mm
▪ Postmenopausal women on estrogen only endo 5 mm
Endometrial hyperplasia
• Localized overgrowth of endometrial tissue
• Can be pedunculated, broad-based, or have a thin stalk
• Color Doppler can reveal a feeding artery in the stalk or pedicle
• Clinical signs: usually asymptomatic but can cause infertility, abnormal bleeding or discovered incidentally during D&C
• Sono: - best imaging is hysterography
o discrete mass, focal, rd. or echogenic discovered in thickened endo w/ possible vascular stalk (color Doppler)
o D/D – endometrial hyperplasia
Endometrial polyps
• Sterile saline injected into UT for detection of abnormal endo
• Indications for procedure:
▪ Infertility & habitual abortion
▪ Congenital abnormalities / anatomic variants of UT
▪ Pre- & post-operative evaluation of UT w/ regard cysts, myomas & polyps
▪ Suspected UT synechiae (i.e. scarring assoc. w/ Asherman’s syndrome)
Saline infusion sonohysterography (SIS)