Urology Flashcards
Management of renal stones
- < 0.5cm
- 0.5 - 2cm
- > 2 cm
<0.5 - increase fluid intake .5-2 = - ESWL (preferred) - Ureteroscopy w/ dorm is basket > 2 cm = - PCNL ( percutaneous nephrolithiotomy)
*** only 1 kidney + stone of any size +/- Anura,fever = Percutaneous nephrostomy
Stent to drain urine first
Stones + fever + hydronephrosis
What does it indicate?
Treatment?
Obstructive Uropathy
Tx - percutaneous nephrostomy
Percutaneous nephrostomy vs percutaneous nephrolithiotomy
Nephrostomy = stoma catheter to pelvicalyceal system for decompression
I.e draining obstructed fluid
Nephrolithiotomy = removal of stone percutaneously via scope
Imaging for suspected renal stone
Non- enhancing CT KUB
Unilateral loin/flank pain + positive hCG =
Suspected ectopic pregnancy
Features of inguinal hernia
Inguinoscrotal swelling - can’t get above it
+ cough impulse
May be reducible
Features of testicular tumours
Investigations required
Discrete testicular nodule / may have associated hydro electric
Symptoms of metastatic disease
- US Scrotum , serum AFP, Beta HCG
Features of acute epididymo-orchitis
Treatment
Dysuria, painful micturition Pain and urethral discharge \+- fever Tender, red scrotal skin \+ve phren’s sign
Tx - antibiotics
Most cases of acute epididymis-or hit is are due to
Chlamydia ( sexually active male)
What is Prehn’s sign ?
Relief of scrotal pain by elevating testicle
Features of epididymis cysts
Diagnostic test
Develop slowly
Can be single or multiple
May contain clear or opalescent fluid
M >40 yrs
- painless, non tender
- lies above and behind testis (upper pole, post part of testes)
= US - diagnostic
Features of hydrocele
Non painful , fluctuate
Clear fluid
Transilluminates
May be presenting feature of testicular ca in young men
Features of testicular torsion
Treatment
Severe, sudden onset of testicular pain
Adolescents and young males
Tender + phren’s sign -ve
Tx - urgent exploratory surgery + fixation *always fix the contra lateral testis
Features of varicocele
Varicosities of pan-pinniform plexus Bag of worms Typically on the left side Dull ache/dragging pain - worse after excercise or at end of the day May show cough impulse
Why does varicocele typically occur on the left side?
Left testicular vein drains into renal vein directly at right angle - high pressure
What can varicocele’s be a presenting feature of ?
Renal cell carcinoma
Renal pain + hematuria + varicocele
Investigation for varicocele
Management
Scrotal Doppler
US is diagnostic
M- reassurance unless in severe pain or infertility
= surgery
Management of testicular malignancy
Orchidectomy via inguinal approach
Treatment of epididymal cyst
Excision via scrotal approach
Management of hydrocele
Children - inguinal approach
- underlying pathology is patent processus vaginalis = processus is fixed.
Adults - scrotal approach
= hydrocele excised or plicated
Major complications of untreated chlamydia/ N. Gonorrhoea in males and females
Males - epididymitis , epididymo-orchitis
Females - salpingitis
Important association of mumps that is not always seen
Or hit is
4-5 days post -parotitis
Local severe pain + tenderness, impalpable testes, swollen scrotum
When do we suspect interstitial cystitis ?
What’s the next step?
Urinary urgency + frequency + suprapubic pain
+ negative culture
- it is a dx of exclusion
Next step - cystoscopy to R/O bladder ca
What is seen on cystoscopy of 10% of patients with interstitial cystitis?
Hunner’s ulcers
1st and 2nd line treatment of interstitial cystitis
1 - bladder training (pelvic floor relaxation) + avoid triggers coffee, NSAIDS for pain
2- amitriptyline, Gabapentin
What is a vesicovaginal fistula?
Common causes
Tract between bladder and vagina
Cause - gynaecological/urinary surgeries esp hysterectomy
- pelvic radiotherapy
Diagnostic test for vesicovaginal fistula?
3 swab test / vaginal gauze test
3 sponges placed in vagina 1 above the other
Bladder - filled with methylene blue via catheter
Swabs removed after 10 mins
RESULTS
Top swab wet but not discoloured - ureterovaginal fistula
Top or middle swab blue - vesicovaginal fistula
Top and middle swab dry, last swab discoloured - urethrovaginal fistula
Cause of stress incontinence
Treatment
Weak bladder outlet
Weak pelvic floor muscles
Tx - pelvic floor excercise (8 contractions/ 3x per day) *of choice
- If fails - surgical retro public mid-urethral tape = free-tension vaginal tape
- If surgery not possible - Duloxetine
Cause of urge incontinence
Treatment
Detrusor over-activity
Tx :
- bladder drill (retraining)
= gradually increase periods between voiding for 6 weeks
- meds - antimuscarininc (immediate release oxybutynin)
Breakdown of LUTS in BPH
Voiding (obstructive) - weak flow, straining, hesitancy dribbling, incomplete emptying
Storage symptoms (irritative)- urgency, frequency, incontinence, nocturis
Post -micturition - dribbling
Complications of BPH
UTI, retention, obstructive uropathy
DRE findings BPH
Firm enlarged smooth
Not nodular
BPH management
Watchful wait
Meds -
-1st line = alpha 1 blockers - tamsulosin, doxazocin, alfuzocin
= side effects - postural hypotension, drowsiness, dyspnea, cough
- 5 alpha reductive inhibitors - finasteride
Surgery - TURP
Tamsulosin vs Finasteride in BPH
Tamsulosin tried FIRST
Finasteride is drug of choice if :
LUTS + prostate enlargement + **RAISED PSA >1.4
Urinary flow obstruction, relieved with catheter
What should be tried before jumping to surgery?
Tamsulosin + refer for trial without catheter (TWOC)
TWOC for 1-2 days after giving Alpha 1 blockers - they relax the smooth muscle of prostate and bladder
The trial is to see if voiding will happen or if further management needed
What is TURP syndrome?
During TURP - excessive irrigation is done to allow good visualisation
Fluid can leak = Dilutional hypOnatremia
= presents as confusion and agitation
What is the most common cancer in adult males in the UK?
Prostate ca
Risk factors of prostate ca
Afro Caribbean
Increasing age
Obesity
Family history 5-10%
Features of prostate ca
Early localised prostate ca - asymptomatic
Other possible features
- BOO - hesitancy, retention
-Hematuria, hematospermia
- pain - back, suprapubic, perineal or testicular
Weight loss
Prostate ca on DRE
What is the appropriate/initial investigation?
Asymmetrical, irregular, hard, nodular enlargement
Loss of median sulcus
I-
1st line = Multiparametric MRI
Serum PSA - most appropriate F/U investigation
When should you suspect prostate ca based on PSA?
40-49 yrs - PSA >_ 2.0 ng/ml
50-69 yrs >= 3
>70 - >= 5
Most common tumours causing bone mets
Prostate
Breast
Lung
Most common sites of bone mets
Spine- = cauda equine syndrome - saddle paresthesia, unable to initiate voiding, back pain —— Urgent MRI spine Pelvis Ribs Skull Long bones
Features of bone mets
Pathological fractures
Hypercalcemia*****
Raised ALP
Increased thirst
Features of local spread of prostate ca
Ureter - occluded ureter
Loin pain & anuria - obstructive uropathy (impaired RFTs)
Bladder ca
Risk factors
Middle age to elderly males/females
Gross painless hematuria
+-
- smoking
Increased age
Exposure to paints, dyes
Unilateral flank pain and anuria post op abdominal surgery
Likely diagnosis?
Investigation
Ureteric injury
I - renal ultrasound
=renal hydronephrosis
Why are patients with sarcoidosis vulnerable to kidney stones?
Hypercalcemia
Sarcoidosis = erythema nodosum, bilateral hilar lymphadenopathy, polyarthralgia, hypercalcemia, fever
Nodosum - tender red nodules over shins
What is the most common malignancy in men aged 20-35?
Testicular ca
Most common type of testicular ca
Germ cell tumour - 95% of cases
GCT divided into seminoma
Non seminomas : incl embryonal, yolk sac, teratoma, choriocarcinoma
Features of testicular ca
Diagnosis
Young man
Painless non tender lump on testis itself
Grows in size
Dx - US 1st line
Request LDH
What increases the risk of testicular ca by x10?
History of undescended testis (crypto-orchidism)
Esp seminoma - Order LDH
CA 15-3 is a marker for
Breast ca
CA 125
Ovarian ca
CA 19-9
Pancreatic ca
CEA
Colorectal ca
PSA
Prostate ca
AFP
Liver (HCC)
Teratoma (testicles,ovaries)
LDH is a marker for
Testicular seminoma
What increases the risk of testicular ca by x10?
History of undescended testis (crypto-orchidism)
Esp seminoma - Order LDH
CA 15-3 is a marker for
Breast ca
CA 125
Ovarian ca
CA 19-9
Pancreatic ca
CEA
Colorectal ca
PSA
Prostate ca
AFP
Liver (HCC)
Teratoma (testicles,ovaries)
LDH is a marker for
Testicular seminoma
Elderly man/woman + hematuria
Suspect ?
Bladder ca
What is the commonest type of bladder ca
Transitional cell cancer
Investigations for bladder ca
Greatest RF?
Flexible cystoscopy = cystourethroscopy
Other - CT urogram- to look for renal & ureteric ca
Investigations for
- > 40 yrs old + frank hematuria
- <40 +hematuria
- Cystoscopy + CT Urogram
2. CT KUB for stones as malignancy less likely
Persistence of hematuria after successful treatment of UTI
>45 + no RF
What should be done?
Refer for urology/nephrology appointment
Routine - 2 week wait
Cystoscopy might be done by urologist
Flank pain + hematuria (micro/gross)+ HTN
What do you suspect?
ADPKD
What is an important association of ADPKD?
Intracranial aneurysm
Features of ADPKD
Autosomal dominant
50% of children will be affected
Can lead to progressive CKD
Diagnosis of ADPKD
Ultrasound - can detect cysts
Hematuria + hemoptysis
Suspected diagnosis
What investigations?
Dx - Goodpasture
Ix- Anti-GBM Abs
Hematuria + renal impairment + bloody diarrhoea
Suspect -
Haemolytic Uremic Syndrome
What is reflux nephropathy?
Urine goes back to kidneys
= dilated pelvicalyceal system = repeated UTIs = progressive renal failure
*young children
Important cause of reflux nephropathy
Congenital abnormality
Dx of reflux nephropathy
Initial
Gold standard
For parenchymal damage (cortical scars)
- Renal US + urinalysis + culture & sensitivity
- MCUG
- DMSA
Management of reflux nephropathy
Initial - low dose antibiotics = trimethoprim daily
If fails or there is parenchymal damage = surgery (re-implant ureters)
Define recurrent UTI
2 UTIs in 6 months
Or
3 UTIs in 12 months
Work up for recurrent UTI
Mid stream urine - microscopy + culture
KUB - look for renal stone
US KUB - stones hydronephrosis, postvoid residual volume
If all normal - cystoscopy
Indications for spiral CT
Ureteric calculi
Pancreatitis
Aneurysm
Prolonged indwelling catheter + UTI
What is this called?
What should be done?
Bluish purple urine bag syndrome - bacterial colonisation
Do urine culture
When should asymptomatic bacteria not be treated?
Indwelling catheter
Non-pregnant female
Adult male
Where can a raised PSA be seen?
Prostate ca
BPH
UTI
After ejaculation, excercise and DRE
** avoid ejaculation 48 hrs before serum PSA
Cystitis is mainly seen due to which organism ?
E.Coli
Dysuria+loin pain + rigours
Likely dx?
Initial investigation?
Acute pyelonephritis
Urinalysis then urine culture
Treatment of:
Upper UTI
Lower UTI
Upper - Cipro or Co-amoxiclav
Lower - Trimethoprim or Nitrofurantoin
Investigation. of:
Hematuria <40 yrs
Hematuria >40
<40 - US followed by CT scan
>40 yrs - cystoscopy
Initial investigation of UTI
Urine dipstick
Management of scrotal trauma
Reassure - if no pain after few hours
Ongoing pain - surgical exploration for fear of testicular torsion
What organism causes acute bacterial prostatitis ?
Gram negative bacteria via urethra
E.Coli most common
Risk factors for acute bacterial prostatitis?
Recent UTI
Urge it all instrumentation
Intermittent bladder catherisation
Recent prostate biopsy
Features of acute bacterial prostatitis
Local Pain - can be referred to rectum and back
Obstructive symptoms
Suprapubic tenderness
DRE findings in acute prostatitis
Tender boggy prostate gland
Management acute prostatitis
14 day course - Quinoloe (cipro, ofloxacin)
Start empirically! Don’t wait for culture result
Consider screening for STIs
Management of recurrent UTIs in post menopausal women
Vaginal oestrogen
= restores premenopausal flora and acidic pH
Improves urogenita atrophy, prolapse and cystocele
If fails - long term ABx
Treatment of:
Upper UTI
Lower UTI
Upper - Cipro or Co-amoxiclav
Lower - Trimethoprim or Nitrofurantoin
Investigation. of:
Hematuria <40 yrs
Hematuria >40
<40 - US followed by CT scan
>40 yrs - cystoscopy
Initial investigation of UTI
Urine dipstick
Management of scrotal trauma
Reassure - if no pain after few hours
Ongoing pain - surgical exploration for fear of testicular torsion
What organism causes acute bacterial prostatitis ?
Gram negative bacteria via urethra
E.Coli most common
Risk factors for acute bacterial prostatitis?
Recent UTI
Urge it all instrumentation
Intermittent bladder catherisation
Recent prostate biopsy
Features of acute bacterial prostatitis
Local Pain - can be referred to rectum and back
Obstructive symptoms
Suprapubic tenderness
DRE findings in acute prostatitis
Tender boggy prostate gland
Management acute prostatitis
14 day course - Quinoloe (cipro, ofloxacin)
Start empirically! Don’t wait for culture result
Consider screening for STIs
Management of recurrent UTIs in post menopausal women
Vaginal oestrogen
= restores premenopausal flora and acidic pH
Improves urogenita atrophy, prolapse and cystocele
If fails - long term ABx