OBG Flashcards
What contraceptives should not be given in women < 20?
Why?
What complications/ side effects ?
Guidance?
Depo-provera = IM medroxyprogesterone acetate
= risk of young age osteoporosis
IUS/ Mirena
Both cause bleeding more days than usual initially + vaginal spotting between cycles
Most females amennorhoeic after use for 1 year
= reassure + advise to come if unscheduled bleeding is problematic
What do you if bleeding becomes problematic after IUS Mirena or Depo use?
COCP for 3 months (while still on depo)
Or
Mefenamic acid or trance mix acid for 5 days
What method of contraception is safe for under 20s?
Nexplanon = etonogestrel implant
COCP
POP
What contraception would you give in a female with learning difficulties?
NO PILLS = COCP POP
- may forget to take them
What are the contraindications of COCP use? (7)
Smoking
Obesity
Thromboembolism hx
Learning difficulty
Postpartum- if breastfeeding CI for 6 mo, if not 6 weeks.
Migraine with aura
HTN - even if well controlled (DONT GIVE)
What are long term methods of contraception?
When should they be avoided?
MIRENA + nexplanon
Avoid if woman has intentions to get pregnant within the next 6 months / nears future
What contraceptive is safe for use while breastfeeding?
POPs - given orally
Short term contraception
How long after delivery are contraceptive methods NOT required?
21 days
How is Depo given and how often?
When is it 1st line?
IM injection - once every 3 months/12 weeks
1st - SCA and Menorrhagia
What do you give young, non sexually active women that complain fo menorrhagia?
Tranexamic acid
What do you give young, non sexually active women that complains of menorrhagia + dysmenorrhea ?
Mefenamic acid
What do you give young, non sexually active women that complain of irregular menses +/- menorrhagia/ dysmenorrhea ?
COCP
Complaints of menorrhagia in female with SCD, what do you give?
Depo - provera
Medication for dysmenorrhea
Mefenamic acid
Medication for metrorrhagia?
COCP
Medication for menorrhagia only?
Tranexamic
What is the 1st line contraceptive method in a sexually active woman with dysmenorrhoea / or fibroids ( do not distort uterine cavity)?
Mirena
If contraindicated =
COCP/POP/implants (if no contraindications)
Uterine cavity distorted - implants = Nexplanon
Emergency contraception for a woman that presented within 3 days of the unprotected sex?
Levonelle pill
Emergency contraception for a woman that presented within 120 hours/5 days of the unprotected sex?
IUD copper
Or
EllaOne pill
What contraception reduces the risk of cervical ca?
Condoms
= reduce risk of HPV infections - therefore reduces risk of ca
How often should nexplanon be replaced?
Every 3 years
= progesterone only subdermal implants
Lower abdominal pain +recent amenorrhoea + vaginal spotting and cervical excitation
Empty uterus on vaginal US
Dx?
Ectopic pregnancy
Management of ectopic pregnancy
- stable
B-HCG
If >1400 - laparoscopy
<1400 - wait and observe - repeat vaginal US later
Management of ectopic pregnancy
- unstable (SBP<90)
Laparotomy - salpingectomy / salpingostomy
Pregnant women + hx of CS comes with profuse vaginal bleeding and severe abdominal pain
She is hypotensive and tachycardic
Dx?
Uterine rupture
Painless vaginal bleeding in late weeks of pregnancy
What do you suspect?
What do you do to rule it out
Placenta Previa
Do TVUS
Painful vaginal bleeding in late weeks of pregnancy + constant abdominal pain
Tender hard abdomen on examination
What do you suspect?
Investigation?
Placenta abruption
Do CTG
3rd trimester
Tachycardia + fever + history of PROM
offensive vaginal discharge
What do you suspect?
Chorioamnionitis
Lower abdominal pain + deep dyspareunia, menstrual irregularities and cervical excitation
Diagnosis?
PID
A women > 51 years old comes with dyspareunia + dysuria
She also complaints of hot flushes and night sweats
Dx?
How to you treat it ?
Suspect post menopausal syndrome
HRT
2ry amenorrhoea after chemo
What do you suspect?
Premature ovarian failure
Painless vaginal bleeding + high placenta
Dx?
Suspect cervical ectropion
Female >51 yo with postmenopausal vaginal bleeding
What do you suspect ?
What investigations are to be done?
Endometrial ca
TVUS - initially to check thickness If thick (>4 mm)- hysteroscopy + endometrial biopsy
What are the commonest cause of postmenopausal bleeding ?
Atrophic vaginitis
Vulvovaginal atrophy
Always TVUS to r/o endometrial ca
Woman of child bearing age + chronic pelvic pain + dysmenorrhea, deep dyspareunia and dyschezia
What do you suspect?
Treatment?
Endometriosis
-NSAIDS + paracetamol
- COCP trial
Laparoscopy - definitive treatment
High fever + lower abdominal pain No vaginal discharge Sexually active, does not use barriers What investigation should done? Dx?
Pelvic US
Turbo-ovarian abscess
Sudden unilateral iliac fossa pain + nausea + vomiting
+/- tender mobile mass
Dx?
Tx?
Ovarian torsion
Refer her to gybe or urgently take to theatre
African women with bloating and heavy regular periods
Enlarged uterus
What do you suspect?
Investigation
Fibroids
TVUS
Investigation for PCOS
Pelvic US
Chronic pelvic pain + worse on standing and during pms
+/- deep dyspareunia
Dx?
Pelvic congestion syndrome
It’s non-organic
Laparoscopy would be unremarkable
1ry amenorrhoea + cyclic pain
Mass in the lower abdomen
Dx?
Hematometra
- Accumulation of blood within uterus
When should VZIG be given ?
- immunocompromised w/ exposure
- pregnant w/ exposure and no VZ antibodies*
- newborns w/ peripartum exposure
*if exposed >2 days before rash appears + immune = reassure
When should oral acyclovir be given in VZV
Pregnant women with chickenpox
Immunocompromised with chickenpox
Pregnant woman , 2nd trimester + non immune + in contact with chickenpox child 7 days ago
Best management ?
VZIG
When is VZIG effective?
If given within 10 days after exposure
Pregnant woman in contact with chickenpox, develops rash
What do you give?
Oral acyclovir w/in 24 hrs
What is the infective period of chickenpox?
2 days before appearance of rash
What are the causes of 1ry postpartum hemorrhage? (4)
4 Ts
Tone - uterine atony = most common *
Trauma - lacerations, incisions, uterine rupture
Thrombin - coagulopathy
Tissues - retained products of conception
Management of uterine atony?
Uterine massage
Oxytocin - uterotonic
How soon after delivery can mirena/IUS be used?
Within 48 hours of delivery or
After 4 weeks - for fear of uterine perforation 2-28 days after birth
What causes shoulder tip pain in ectopic pregnancy?
Peritoneal bleeding + peritonism
Initial investigation in ectopic?
Urine pregnancy
If +ve = TVUS
- if empty uterus =b HCG
Management of ruptured uterus
Urgent laparotomy
Risk factors of uterine rupture (3)
Previous CS or uterine surgery **
Excessive oxytocin - uterotonics
Unrecognised obstructed labour
First investigation to be done in suspected placental abruption?
What is the management?
CTG
If distressed - urgent CS
If normal - vaginal US to r/o previa
Post menopause sx
Management :
- if uterus
- no uterus
Uterus - HRT or transdermal estradiol & progesterone patches
No uterus or IUS in place - oestrogen only HRT
*progesterone given w/ estrogen to protect uterus against endometrial ca
Post menopausal smoker - how is HRT given?
Transdermal
Oral has higher risk for VTE
What are the 2 types of HRT?
1- sequential /cyclical
= 1st 12 months of menopause/perimenopause
- oestrogen daily / progesterone cyclically
2- continuous combined HRT
= last menstrual > 12 months
- oestrogen + progesterone taken daily
What is chorioamnionitis?
Inflammation of foetal amnion and chorion membranes - typically due to ascending bacterial vaginal infection when there is ROM
Major RF for chorioamnionitis
PROM
Due to ascending bacterial infection
Features of chorioamnionitis
Hx PROM
Maternal tachy followed by fever
+ foetal tachy
Suprapubic tenderness/ and pain and contractions
Aminiotic fluid - purulent/offensive/foul smelling yellow or brown
*sometimes no fever because tachy occurs before
Fundal height landmark for 12 weeks
Public symphysis
Fundal height landmark for 20 weeks
Umbilicus
Fundal height @ 20-36 weeks =
GA in weeks +/-2 = ____ cm
Fundal height landmark @ 36-40 weeks
Xiphoid process of sternum
Cause of large for date uterus (4)
Hyatidiform mole
Concealed accidental hemorrhage
Tumours as fibroids/ ovarian cysts
Foetal malformations (hydrocephalus)
Cause of small for date uterus
Foetal death
IUGR
Pregnancy during amenorrhoea
Malpresentation - transverse lie
Any female <25 that uses Mirena + develops abdominal pain and irregular menses
Suspect -
PID
What is a major RF for PID
-IUS - mirena
=allleviate symptoms of endometriosis adenomyosis and fibroids
*IU system = mirena IUDevice = copper T
Features of trichomoniasis
trichomonas vaginalis frothy yellowish- greenish smelly vaginal discharge \+ vaginal itching On examination - strawberry cervix Vaginal pH >4.5
Treatment of trichomoniasis
Oral metronidazole
Features of bacterial vaginosis
Grey-white fishy, thin discharge VERY offensive Itching uncommon \+ve whiff test - potassium hydroxide Vaginal pH >4.5
Whiff test for diagnosis of ?
Bacterial vaginosis
Gardnerella vaginalis
Treatment of bacterial vaginosis
Metronidazole + clindamycin
What is the normal vaginal pH
3.8 - 4.5
Thick white cottage cheese discharge
Odourless
Vaginal pH 4-4.5
Diagnosis?
Vulvovaginal candidiasis
- Candida albicans
Treatment of vaginal candidiasis
Local clotrimazole
Most common abnormal vaginal discharge in chilbearing age
Bacterial vaginosis
What is Amsel’s criteria?
Diagnostic criteria for BV - 3/4 = diagnosis
- homogenous grey white discharge
- positive whiff test ( fishy smell when you add koh)
- clue cells on microscopy
- vaginal pH > 4.5
Prolonged amenorrhoea in a woman <40
Suspect-
Diagnostic investigation
Treatment
Premature ovarian failure
Ix - FSH
FSH > 25 IU/L on 2 occasions 4 weeks apart - diagnostic
T - HRT until 51 years old
What is early menopause?
Investigation
Amenorrhoea in 40-45 years old
I - US
Presentation of premature ovarian failure
Amenorrhoea / oliguria - commonest presentation
Postmenopausal features
Infertility
Cause of POF
Most common - idiopathic
Can occur after chemo !
Presentation of atrophic vaginitis
Atrophic vaginitis = vulvovaginal atrophy = genitourinary syndrome (GSM)
Urinary = dysuria, frequency, incontinence, etc
+/-
Dyspareunia, vaginal itching/dryness
Cause of atrophic vaginitis
Treatment
Oestrogen deficiency after menopause
Treatment = topical oestrogen (intravaginal or cream)
- if + other menopausal symptoms = HRT or transdermal oestradiol + progesterone patch
Screening test for colorectal ca
Age it is done + frequency
Fecal immunochemical test (FIT)
60-74, every 2 years
Breast cancer screening test
Age it is done + frequency
Mammogram
50-70, every 3 years
If high risk - 40-70 years, annually .
Cervical ca screening test
Age it is done + frequency
Pap smear , cervical smear - cytology, HPV
25-49, every 3 years
50-64, every 5 years
Cervical ectropion management
***Reassure if there is NO bleeding or pain after sex
If symptoms are bothersome - do cervical smear
= if normal - cryotherapy, diathermy, cautery with silver nitrate
It is not a risk factor for cervical ca
What is a cervical ectropion
Stratified squamous ectocervix is replaced by
I
Columnar epithelium
= happens in high oestrogen states = pregnancy COCP puberty
Asymptomatic , but can have painless vaginal bleed or non purulent watery discharge post-coital
Symptomatic ectropion
Next step?
Refer to colposcopy
Pre-eclampsia
- def
- RF
- Tx
HTN + proteinuria > 0.3g/24 hr
Usually after >20th week gestation
RF - 1st pregnancy , pregnant teens, women >40
Tx - no cure! Except for delivery !
Mild - conservative treatment to allow baby to mature under close monitor
Medications given in pre-eclampsia
MgSo4 to prevent seizures
Corticosteroids to allow for baby maturation
Labetalol to lower BP
Foetal complication of pre-eclampsia
Risk of pre-term delivery
Oligohydramnios
Sub -optimal foetal growth
Maternal complication of pre-eclampsia
Liver + kidney failure
Clotting disorders
HELLP syndrome
What is HELLP syndrome
Complication of preeclampsia
Hemolysis - low HB
Elevated Liver enzymes
Low Platelets
Features - epigastric/RUQ pain +- NV =/- dark urine (hemolysis) =/- HTN
Treatment of HELLP
Deliver baby
MgSo4 if seizures develop
Features of AFLP (acute fatty liver of pregnancy)
ELLP - raised liver enzymes + low platelets
Low glucose
+- raised ammonia
Features of Disseminated intravascular coagulation (DIC) on labs
High PT PTT & bleeding time
Low platelets & fibrinogen
DIC triggers
Sepsis, surgery, major trauma, cancer , complications of pregnancy
Post menopausal bleeding
Initial test
Diagnostic/ most definitive step
Most likely dx
Initial - TVUS
Def - hysteroscopy with endometrial biopsy
Dx - atrophic vaginitis but most worrisome is endometrial ca
Risk factors for endometrial ca (7)
Obesity Nulliparity Unopposed oestrogen (oestrogen, no progesterone) PCOS Tamoxifen Early menarche Late menopause DM
What can reduce risk of endometrial ca
Progesterone
What is antiphospholipid syndrome associated with
What can be done?
Recurrent miscarriages
- to avoid = give aspirin + LMWH
Who should you screen for antiphospholipid syndrome
Females w/ recurrent abortions ( 3 or more miscarriages) in 1st trimester (<13 weeks HA)
+
1 o more abortions in 2nd trimester
What does screening for antiphospholipid syndrome include
Lupus anticoagulants
Anti-cardio lip in antibodies
Anti-B2 glycoproteins -1 antibodies
Clinical features of endometriosis
Chronic pelvic pain
Dysmenorrhoea
Deep dyspareunia
Can have sub fertility, urinary symptoms and dyschezia
Gold standard investigation / most definitive investigation
Laparoscopy
Management of endometriosis
1st line - NSAID /paracetamol
If it doesn’t help - hormonal treatment
= COCP trial or progesterone 3-6 months before laparoscopy
If fertility is an issue - lap first
Causative organisms of PID
Chlamydia trachomatis - most common
Neisseria gonorrhoea
Features of PID
Pelvic/ Lower abdominal pain Fever Deep dyspareunia Cervical excitation Vaginal/cervical discharge Dysuria + menstrual irregularities
Investigation for PID
Chlamydia + gonorrhoea screening
Common risk factors for PID
<25 years old IUS Multiple partners Previous STIs Uterine instrumentation
Complications of PID
Infertility - 10-20 % risk
Turbo-ovarian abscess = if left untreated or not treated properly
Ectopic pregnancy
Chronic pelvic pain
Lower abdominal pain + tenderness + high fever
No discharge
Suspect?
What investigation to be done?
Turbo -ovarian abscess
Pelvic ultrasound
Management of PID
Outpatient
- oral ofloxacin + oral metronidazole
Inpatient
-IM ceftriaxone + oral doxycycline + oral metronidazole “CDM”
Treatment of cervicitis
Chlamydia
N.gonorrhoea
Chlamydia - doxy (1st line) 100 mg bid 7 days
2- or azithromycin 1g PO + 500 mg PO OD for 2 days
Neisseria gonorrohea
- ceftriaxone 1gm IM single dose
Or
Cipro 500mg PO single dose
Difference between cervicitis & PID
Cervicitis - has vaginal discharge , no ascending infection so no pelvic pain
PID involves adnexa and genital structures - pelvic pain, deep dyspareunia, cervical excitation