Respiratory Flashcards

1
Q

Most common organism in bronchiectasis

A

H influenza - most common
Pseudomonas aeruginosa
Klebsiella
Strept pneumoniae

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2
Q

Main features of bronchiectasis

A

Chronic persistent cough
Copious excessive sputum
Recurrent respiratory tract infections

Clubbing - not specific, not always present

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3
Q

Tramlines , cysts/ring opacities on CXR

A

Bronchiectasis

*CXR can often be normal

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4
Q

How do you confirm dx

A

HRCT

= shows bronchial dilatation and wall thickening w/ ground glass opacities

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5
Q

Management of bronchiectasis

A

Bronchiectasis = permanent dilation of airways 2ry to infection/inflammation

-chest physio
-postural drainage
- ABx treatment in exacerbation / long term in severe cases
-bronchodilators - selected cases
Immunisation
Surgery - selected cases = e.g localised disease

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6
Q

Features of life threatening asthma (11)

A
Altered mental status w/ drowsiness
Silent chest 
Poor resp effort
Exhaustion
Cyanosis
Arrhythmia 
Hypotension
PEF <33% predicted or best
Spo2 < 92%
PaO2 <8
Paco2 = normal = 4.6-6 kpa
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7
Q

Suspect mesothelioma or bronchial carcinoma when ….
(Malignant tumour of mesothelial cells)

How do you confirm dx?

A

Worker - builder , shipyard worker etc
Asbestos exposure
SOB + chest pain + weight loss
Clubbing, recurrent pleural effusion

Pleural BIOPSY (not cytology)

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8
Q

Asbestos exposure in ..

A

Firefighters
Construction workers
Power plant workers
Shipyard etc

Veterans

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9
Q

Who should deaths from mesothelioma be reported to and why?

A

It is an industrial disease - leads to unnatural death
Report/ consult coroner
Compensation often available

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10
Q

60 y/o builder, Smoker , Comes with SOB + chest pain
CT - irregular pleural thickening
CXR - mediastinal lymphadenopathy + rt sided pleural effusion
Dx, cause ?

A

Mesothelioma
Cause - asbestos
80% of mesotheliomas are due to it
If he dies - refer to coroner

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11
Q

When should you suspect atelectasis?

A
Dyspnoea 
Tachycardia 
\+/-Fever
Hypoxemia 
Within 72 hrs post op
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12
Q

Management of atelectasis

A

Chest physio

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13
Q

Common cause of tension pneumothorax

A

Mechanical ventilation

- suspect if pt suddenly deteriorates and develops low O2 sat + hypotension

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14
Q

Management of pneumothorax

A

High O2 initially
Needle decompression - large bore 2nd ICS mid clavicular line
Chest drain

If pt stable - CXR

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15
Q

Features of cardiac tamponade

A

Becks triad = hypotension , muffled heart sounds, high JVP (distended neck veins)
CXR - large globular heart - pericardial effusion or tamponade

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16
Q

Dx + Tx of cardiac tamponade

A

Echo

Urgent pericardiocentesis

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17
Q

Primary spontaneous pneumothorax
Consider in …
Initial dx?

A

Tall thin males - dyspnoea + chest pain
No apparent reason, NO hx of lung disease
Dx = erect CXR if pt not severely distressed
Other wise proceed to needle decompression

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18
Q

Secondary spontaneous pneumothorax

Initial management

A

Occurs spontaneously
In presence of underlying lung disease - asthma, COPD

If pneumothorax = 2cm air rim (<= 50%) — aspirate/insert cannula

If >2 cm - insert chest drain

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19
Q

Haemothorax vs pneumothorax

A

No distended neck veins in haemothorax

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20
Q

Treatment of community acquired pneumonia

Mild

A

Amoxicillin

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21
Q

Treatment of community acquired pneumonia

Moderate

A

Amoxicillin + clarithromycin

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22
Q

Treatment of community acquired pneumonia

Severe

A

Co-amoxiclav +clarithromycin

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23
Q

Treatment of pneumocystitis jirovecii

P.Carinii

A

Co trimoxazole
(Trimethoprim + sulfamethoxazole)
AKA Bacterim

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24
Q

In case of
-severe allergy to penicillin
-pt is on statins
What antibiotics should be given in community acquired pneumonia

A

AVOID Cephalosporin - cefuroxime in severe allergy - 10% cross reactivity clarithromycin

AVOID clarithromycin - if on statins - risk of rhabdomyolysis

GIVE doxycycline

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25
Features of sarcoidosis (5)
Bilateral hilar lymphadenopathy - most common CXR finding Erythema nodosum - tender red nodules over shin Polyarthralgia Hypercalcemia Fever Consider DX if 2 or more features seen
26
What syndromes are associated with sarcoidosis
Lofgren’s syndrome = acute form of sarcoidosis - BHL, EN, fever, polyarthralgia - excellent prognosis Heerfordt’s -uveoparotid fever Parotid enlargement fever and uveitis 2ry to sarcoidosis
27
What is sarcoidosis
Multisystem disorder Unknown aetiology Characterised by non caseting Granulomatosis Common young adults and people of African descent
28
Causes of oral thrush | Features
Inhaled corticosteroids Immunosuppression Smoking Think white marks - can be rubbed out ***
29
Treatment of oral thrush
Oral fluconazole 50mg OD 7 days | Good inhaler techniques, spacer device, rinse mouth after use
30
Long term asthma management 4 steps
1. SABA - salbutamol I if not controlled i.e >3 doses/week 2. SABA + inhaled corticosteroids(ICS) (beclometasone) 3. SABA + ICS + LTRA (leukotriene receptor antagonist) 4. SABA + ICS + LABA +/-LTRA LABA = salmeterol 5. SABA + ICS + LABA +/-LTRA + increased dose of ICS If fails SABA + LTRA + triall of new drug/further increase in dose
31
Difference b/w NICE and BTS guidelines for asthma management
Step 3 BTS - LABA (salmeterol) NICE - LTRA (montelukast)
32
Side effects of beclometasone
Oral/ pharyngeal candidiasis Sore throat Dry mouth/throat
33
Excercise induced asthma management
SABA 2. SABA +ICS 3. SABA+ICS+ LTRA (preferred) or LABA or sodium cromoglicate
34
Drugs that aggravate asthma
Beta blockers Aspirin NSAIDs
35
Signs on examination - asthma
Expiration wheeze Reduces PEFR (peak expiratory flow rate) FEV1/FVC < 70% and improves with bronchodilators
36
Asthma vs COPD
FEV1/FEV <70% (<0.7) = asthma , improves with bronchodilator COPD - remains < 0.7
37
Obstructive vs restrictive lung disease
Obstructive - FEV1/FVC < 70% or 0.7 Asthma, COPD, emphysema, bronchial it is Restrictive > 70% Interstitial lung disease, chest wall deformities, pulmonary fibrosis
38
Dx of asthma
Clinical Or via spirometry If however spitometry is Norma but patient has adopt or FHx of asthma or is clinically asthmatic = peak flow diary
39
Use of peak flow diary
Helps determine appropriate time for use of bronchodilators
40
What is FEV1 and FVC
FEV1 - forced expiratory volume = volume exhaled @ end of forced expiration 1s FVC - forced vital capacity - volume exhaled after maximal exhalation following full inspiration
41
Spirometry results asthma
FEV1- significantly reduced FVC - normal Ratio <0.7 and reversible with bronchodilators
42
Side effect of beta blockers
Bronchoconstriction Atenolol, “lol”s
43
Side effect of beta agonist
Tachycardia Salbutamol
44
Pneumonia that does not improve with ABx + night sweats or weight loss or new pleural effusion Suspect?? What do you do?
Empyema, pleural aspiration - sent for C&S Chest drain = for treatment of confirmed empyema or compromising effusion
45
Causes of empyema
Complication of pneumonia - common Penetrating chest trauma Oesophageal rupture Complication of lung surgery
46
SIADH is seen in
Small cell lung ca | SIADH = low serum Na, low serum osmolality, HIGH urine osmolality
47
Small cell cancer of the lung causes (2) - -
SIADH | Cushing
48
SCC of the lung cause what metabolic imbalance
Hypercalcemia
49
SIADH vs diabetes inspidus
``` SIADH = low serum Na, low serum osmolality, high urine osmolality DI = hypERnatremia, high serum osmolality, low urine osmolality ``` *low urine osmolality in DI increases after vasopressin given
50
Histopathology of SCC
Large polygonal cells w/ keratin pearls & bridges
51
What is COPD | Most common cause
Chronic bronchitis + emphysema | Smoking
52
Features of COPD (6)
``` Smoking history Progressive dyspnoea FEV1/FVC <0.7 irreversible Hyper inflated chest on CXR, Productive cough Wheeze ```
53
What can develop in severe COPD
Right sided heart failure | - peripheral oedema
54
Spirometry of COPD
FEV1/FVC <0.7 FEV1 <80% predicted Increased RV - due to air trapping
55
CXR of COPD
Hyperinflation flat hemidiaphragm >7 posterior ribs seen
56
What is chronic bronchitis | Most common cause
Form of COPD = productive cough > 3 months + progressive dyspnoea, wheeze, low grade fever Tobacco smoking
57
Management of COPD
Stop smoking ! 1st line - SABA or SAMA (muscarinic antagonist) 2nd line - add LABA +LAMA If asthmatic features present LABA +ICS If still breathless LAMA + LABA + ICS
58
Long term O2 therapy in COPD - when? (5) | LTOT = supplementary O2 for at least 15hrs/day
``` Severe airflow obstruction pneumonia FEV1 <30% predicted (Consider assessment if 30-49%) Sats < 02 on RA Polycythemia Cyanosis Peripheral oedema , raised JVP ```
59
When should oral theophylline be used in COPD
NICE : after trials of SA/LA bronchodilators or to people that can’t use inhaled therapy
60
If COPD patient is already on LTOT but is still breathless | What should be done?
Start on prednisolone or nebuliser normal saline to loosen secretions
61
Management of COPD exacerbation
20-28% O2 via Venturi mask Maintains sats b/w 88-92% Nebs - salbutamol w/ ipratropium IV hydrocortisone 100mg or 30 mg pred stat -(continue as 30mg OD for 7-14 day) If no response - IV aminophylline Give antibiotic if purulent sputum, fever, high CRP If after all this there’s dyspnea to evidence of acidosis = NIV Failed NIV —- intubate
62
Management of acute asthma exacerbation paediatric
O2 Salbutamol nebs Ipratropium nebs Corticosteroids - oral pred / iv hydrocortisone If still excacerbated - IV salbutamol IV aminophylline IV MgSo4
63
Management of acute asthma exacerbation - adults
O2 > salbutamol nebs 5mg or terbutaline nebs +O2 Corticosteroids - 100 mg IV hydrocortisone or 40-50 mg pred oral Severe/not improving/ life threatening - back2back salbutamol nebs every 15 mins + ipratropium 0.5 mg to the nebs Single dose MgSo4 1.2-2g over 20mins If improving salbutamol nebs q4hr + pred 40-50 mg PO OD 5 days
64
Asthma exacerbation | Adults vs children treatment
O2 > salbutamol nebs | 3 step A- corticosteroids C- ipratropium
65
Uses of MgSo4
Eclampsia Torsasdes des pointes Refractory asthma excacerbation - after no response to salbutamol, hydrocortisone,ipratropium bromide
66
SCC vs lung adenocarcinoma
SCC - smokers | Adeno - non smokers
67
Differentiating pneumonia 1. Herpes labialis 2. Erythema multiforme (target lesions) 3. Atypical - young adult, dry cough, bilateral consolidation 4. HIV w/ CD4 <200 + desat on excercise 5. After flu
1. StreptococcaL/pneumococcal 2. mycoplasma 3. mycoplasma 4. Pneumocystis jirovecii ( carinii) 5. Staph aureus
68
Pneumonia after exposure to water Staying in hotel Low Na low lymphocyte Tx?
Legionella Macrolides - clarithromycin, azithromycin Or tetracycline
69
CURB 65 to determine outpatient or admission treatment
``` C - confusion AMT score <=8/10 U- Uremia (urea > 7 mmol/l) R- RR >=30/ min B- SBP <=90 or DBP <= 60 65 - age >=65 ``` Home treatment - score 0-1 low risk, <3% mortality risk Hospital care - score 2 or more, 3-15% mortality risk ICU - score 3 or more - high mortality risk >15%
70
Prophylaxis antibiotics in HIV CD4 < 200 CD4 < 50
< 200 - cotrimoxazole (against jirovecii) | <50 - azithromycin (mycobacterium avium)
71
Initial investigation in suspicion of lung ca | How do you confirm dx?
CXR Dx - bronchospy Biopsy to obtain histological/cytological specimens
72
Post op prophylaxis for DVT / pulmonary embolism
Enoxaparin (LMWH) - ideal
73
Treatment of VTE/PE/DVT
If not pregnant DOACS - apixaban , rivaroxaban 1st line If pregnant - LMWH Warfarin and DOACS contraindicated in pregnancy
74
RF for pulmonary embolism (6)
``` COCP Surgery Obesity Pregnancy Malignancy Previous VTE ```
75
Investigation of choice for pulmonary embolism
CTPA
76
Main causes of travellers diarrhoea
Campylobacter jejuni- gram neg Salmonella “” Self limiting, treat in elderly/immunocompromised Sam - cipro Camp - erythromycin/clarithromycin ; 2- cipro
77
Most common organism causing pneumonia | Treatment
Strept pneumoniae Gram + Associated w/ herpes labialis Mild - amoxicillin Mod - amoxicillin + clarithromycin Sev - co amoxiclav + clarithromycin Allergic — doxycycline
78
Most common organism causing UTI | Treatment
E. coli Acute pyelonephritis- culture then start antibiotics Upper UTI - cipro / co amoxiclav Lower - trimethoprim or nitrofurantoin
79
Horners syndrome
Ptosis, mitosis, anhidrosis Due to compression of sympathetic chain Pan coast tumour
80
Pan coast tumour
Tumour of apex of lung Spreads to nearby tissue- ribs, vertebrae Unilateral compression of sympathetic chain - horners syndrome Most pancoast = non small cell lung ca
81
Acid base imbalance seen in pulmonary embolism
Repiratory alkalosis
82
Acid base imbalance seen in asthma & COPD
Resp acidosis
83
Panic attack vs pulmonary embolism - acid base
Both resp alkalosis | PaO2 normal in panic attack , low in PE
84
Drugs that cause metabolic acidosis
``` MAIIAD Metformin Aspirin (later on) Iron Isoniazid Alcohol Digoxin Paracetamol - less common ```
85
Causes of metabolic acidosis
Drugs - MAIIAD Diarrhoea Renal insufficiency Addison’s disease
86
Drugs that cause metabolic alkalosis
ACEi NSAIDs diuretics (ADD)
87
Causes of metabolic alkalosis
Drugs - ADD Vomiting - loss of gastric acid Hypovolemia, hypokalemia 2ry hypoparathyroidism
88
Respiratory acidosis causes -
Drugs - benzo, organophosphate COPD asthma Pneumothorax haemothorax Ascites
89
Respiratory alkalosis causes
``` Any cause of hyperventilation Pulmonary embolism Panic attack Salicylate Aspirin (early) ```
90
Features of pulmonary fibrosis
Progressive excertional dyspnoea Bi-basilar fine crepes - end inspiratory Dry cough Clubbing *coal mines
91
Anticipatory meds 1. Pain & breathlessness 2. Nausea & vomiting 3. Anxiety delirium agitation 4. Noisy resp secretions
1. SC morphine 2. SC haloperidol 3. SC midazolam 4. SC hyoscine butylbromide
92
``` Hypersensitivity pneumonitis/ extrinsic allergic alveolitis Causing organism Birds Farmer Malt Mushroom, ```
Bird fancier - avian protein Farmer** - saccharopolyspora rectivirgula / micropolyspora faeni Malt worker - aspergillosis clavatus Mushroom worker - thermophilic acctinomycetes
93
EAA/ hypersensitivity pneumo Presentation Investigation
SOB, dry cough fever - 4-8 hrs after exposure (acute) Chronic I - CXR upper/mid zone fibrosis = diffuse micronodular interstitial shadowing Bronchoalveolar lavage - lymphocytes is No eosinophilia in blood
94
``` Paraneoplastic syndrome : lung ca Small cell (3) ```
SIADH ACTH - atypical, hyperglycaemia hypoK, HTN , alkalosis, muscle weakness Lambert-Eaton = presents like myasthenia but reflexes absent, elicited after excercise Increas in strength + power after repeated tests
95
Paraneoplastic syndrome : lung ca | SCC (5)
``` Hypercalcemia PTH-rp secretion Clubbing Hypertrophic pulmonary osteoarthropathy Hyperthyroidism- due to ectopic TSH ```
96
Resp alkalosis | Pulmonary embolism vs panic attack
Panic attack - PaO2 normal , pco2 low | PE - both low
97
Aspirin toxicity | Acid base disturbance
Early - resp alkalosis | Late - metabolic acidosis
98
Side effects SABA
Tachycardia Palpitations Tremors Shaky hands
99
Where is mixed acidosis seen? | Management
Cardiac arrest Low pH, high PaCO2 , low HCO3 - accumulation of CO2 , kidneys not over fused due to low cardiac output Increase ventilation to washout CO2
100
First step of stable asthma management
SABA + low dose corticosteroids
101
How to clean spacers for inhalers
Monthly Soak in detergent/warm water 15 mins Air dry (not in sun) Replace spacer every 12 months
102
Bronchopleural fistula is complication of
Lung cancer surgery - most common pulmonary resection, pneumonectomy > lobectomy More common in rt sided lung surgery Can also develop after chemo, radio, or infection
103
Dx of broncho-pleural fistula | Treatment
CT chest Xray may show it Tx - repair the fistula = endoscopy, bronchoscopy, open chest surgery
104
Managing PE in pregnancy
LMWH - throughout pregnancy and at least 3 months after treatment has been given
105
Types of respiratory failure
Type 1 - hypoxia w/o hypercapnia = pneumonia , low o2 in air -low po2 / pco2 low/normal ``` Type 2 Hypoxia + hypercapnia Reduced breathing effort Asthma COPD ``` Low po2 + high pco2
106
Methotrexate pneumonitis Features Imaging Management
Dry cough SOB fever Starts w/in 1st year of methrotrexate initiation CXR - hazy opacity , prominent reticulation HRCT chest Mgmt - methotrexate needs to be stopped
107
Common organisms causing cellulitis | Common site
Strept pyogenes Staph aureus Cellulitis- inflammation of skin and subcutaneous tissue Shins
108
Management of cellulitis
1 . Flucloxacillin 2. Clindamycin or clarithromycin (if penicillin allergic) Oral clindamycin if fails to respond to flucloxacillin e.g. MRSA Severe cellulitis - IV benzyl penicillin + flucloxacillin MRSA - Vancomycin
109
What is lichen planus
4P + F - pruritic, purple , papular, polygonal rash on flexor surfaces LP - white lacy pattern on buccal mucosa
110
Management of lichen planus
Topical steroids - mainstay Benzydamine mouthwash or spray - recommended Extensive lichen planus - oral steroids / immunosuppression
111
Suspicion of malignant melanoma
Asymmetry - 2 halves look different in shape B - irregular border / edges C- diffeernt shades of black, brown , pink Diameter- >6 mm Evolves/enlarges - grows upwards /downwards/ outwards as flat lesion
112
Benign mole - doesn’t bleed Patient wants it removed What do you do ?
Refer to private dermatologist | No cosmetic services - NHS
113
Breslow thickness - single most prognostic variable in malignant melanoma
< 1 mm - 95-100% 5 year survival 1-2 mm 80-95% 2.1 - 4 mm - 60 -75% > 4 mm - 37 -50%
114
Cardiac & renal manifestations of SLE
Pericarditis Proteinuria Glomerulonephritis - diffuse proliferative
115
Anti-histone is seen is
Drug induced lupus | Due to isoniazid or hydralazine or procainamide ( TB , HF)
116
Initial screening test for SLE / most sensitive
ANA
117
Confirmatory test for SLE
Anti dsDNA | Highly specific
118
Drug induced lupus vs SLE
DIL: Renal and nervous system involvement rare in drug induced Usually resolves after stopping It is ANA positive+ dsDNA NEGATIVE + anti histone antibodies
119
Most common drugs that cause drug induced lupus
Procainamide - antiarrythmic Hydralazine - vasodilator Less common - isoniazid (anti-TB),minocycline, phenytoin
120
Acute vs chronic urticaria
Acute - <6 weeks | Chronic - >6 weeks
121
Drugs that can cause urticaria
Aspirin Opiates They release histamine from mast cells
122
Management of urticaria
Treat aggravating cause - stop aspirin, opiates, overheating, stress, alcohol, caffeine Antihistamine (non sedating) = cetirizine, loratidine If pregnant - sedating antihistamine - chlorphreniramine
123
Key features psoriasis
``` Itchy elevated plaques w/ overlying white silver scales Elbows knees scalp Not contagious Extensor surfaces! Strong genetic basis/ family history Auspitz sign Kobners reaction ```
124
Auspitz sign
Seen in psoriasis | Pin point bleeding after scraping
125
Kobner’s reaction
New lesions at sites of skin injury
126
Treatment of psoriasis
Topical corticosteroids Vitamin D analogues Tar preparations
127
Key features of eczema
Itchy red rash Skin creases - flexures - wrist , elbow folds, behind knees Environmental triggers / URTI FHX of atopic disease Typically appears before age 6 mo , clears by 5 yrs in 50%, 75% by age 10
128
Treatment eczema Mild
Emollients - 1st line Topical steroids = mild - hydrocortisone acetate .5/1/2.5% (mild case , new eczema no response to emollients)
129
Sebhorreic dermatitis - key features
Scaling rash Affects sebaceous glands Face scalp chest - inflamed greasy areas + scaling / dandruff on scalp Inflammatory reaction to yeast
130
Treatment sebhorreic dermatitis
Regular anti fungal | Intermittent topical steroid
131
Oral thrush vs leukoplakia
OT can be rubbed out ( thick white marks +/- inflamed mouth and tongue Leukoplakia - sharp well defined edges , cannot be rubbed out
132
Treatment oral thrush
Oral fluconaxole 50 mg OD 7 days Or Fluconazole oral suspension
133
Leukoplakia treatment
Stop smoking | Take biopsy as they are premalignant
134
Eczema - infants - younger children Older children
Infants - face + trunk > extremities YC - extensor surfaces OC - flexor surfaces , creases face+ neck
135
Treatment eczema | Moderate
Betamethasone valerate .025% Clobetasone butyrate .05% = wide area of drynesss , crackling , redness
136
Eczema - severe | Treatment
Potent strength Beclomethasone valerate .1% Mometasone .1% Hydrocortisone butyrate Eczema that causes bleeding/ prevents sleep due to itching / no response to emollients and hydrocortisone Very potent = clobetasol propionate
137
How should emollients be used with steroids
Apply emollient first - wait 30 mins | Apply topical steroid
138
Antifungal for Athletes foot Fungal groin infection Fungal nappy rash
Clotrimazole
139
Itching w/o sign and symptoms of anaphylaxis give ___ | If reaction is severe __
Oral anti histamine Severe - IM adrenaline
140
Basal cell carcinoma / rodent ulcers Features Most common type
Slow growth ,Local invasion Mets extremely rare,Most common type of ca in western world Sun exposed sites - head neck majority Nodular BCC Initially Peary /flesh coloured w/ telangestasia > ulceration leaving central crater
141
Pearly white umbilicated ulcer w/ central depression
BCC
142
BCC management
Surgical removal/ cryotherapy Topicals - imiquimod, fluorouracil Radiotherapy
143
Molluscum contagiosum Features Treatment
``` Pox virus White/pink Pap ulcers w/ umbilicated/depressed central puncture Anywhere on skin Cheesy/white material when squeezed Children + immunocompromised commonly ``` Tx - resolve spontaneously w/in 6-24 months
144
Organism that causes impetigo
Staph aureus / strept pyogenes | Impetigo = superficial bacterial skin infection
145
Impetigo
1ry / 2ry complication of existing condition ; eczema, scabies, insect bite Children commonly ; in warm weather Face + flexures , limbs not covered Contagious - spreads by direct discharge / indirect spread
146
Impetigo features Appearance Incubation
Incubation - 4-10 days Golden crusted skin lesion - honey coloured crust Very contagious