Cardiology Flashcards
Unstable angina vs NSTEMI
UA- no ST elevation and troponin normal
NSTEMI - no ST elevation , troponin raised
What is acute coronary syndrome?
STEMI NSTEMI UA
RFs for ischemic heart disease - unmodifiable (3)
Age
Male gender
Family history
RFs for ischemic heart disease - modifiable (5)
Smoking
Diabetes, HTN , high cholesterol, obesity
Likely occluded artery in an inferior MI
What leads would you see ST elevation
Right coronary
2,3, AVF
ST elevation leads I, avL,V5 ,V6
Likely occluded artery ?
Are of infarct ?
Left circumflex
Lateral MI
Anterior/anteroseptal MI
ST elevation in what leads
Likely occluded artery
V1-V4
LAD
Anterolateral MI
ST elevation in what leads
Likely occluded artery
1, avL, V4 V5 V6
LAD or left circumflex
Features of left main coronary artery (LMCA) occlusion on ECG
What should be done?
Widespread ST depression
ST elevation in aVR
Emergency coronary angio
STEMI - management acute
MONA - IV morphine, O2, Nitrates, Aspirin 300 mg Presentation : Within 12 hr of sx onset: - 1ry PCI = gold standard If unavailable or 12 hrs - thrombolkysis ( Alteplase preferred)
Long term management of MI
- Aspirin , ACEi , statins - lifelong
- Ticragrelor or Prasugrel - 12 months OR clopidogrel
- B-blockers 12 months (atenolol, bisoprolol)
Statin 80 mg OD PO
AABC+S
NSTEMI / UA management
Give ASAP :
300mg Aspirin +
LMWH (enoxaparin, dalteparin) or Fondaparinux = SC
- no high risk of bleeding and no angio in next 24 hrs
- if angio likely in next 24 or creatinine >265 give
=unfractionated heparin - IV
Intermediate/high risk of=adverse cardio event ( predicted 6 month mortality > 3% :
angio w/in 96 hrs of admission
Intravenous glycoprotein receptor antagonist
= eptifibatide or tirofiban
Becks triad
Hypotension
Muffle heart sounds
Raised JVP
= cardiac tamponade
Cardiac tamponade
- causes
- features
Becks triad
Can develop as MI complication
Most important cause is trauma
CXR - enlarged globular heart
Dx - echo
Complications of MI
Arrest - VFIB - mcc of death after MI CHF Acute pericarditis Dressler syndrome Left ventricular aneurysm Acute mitral regurgitation VSD, MR Pericardial effusion Cardiac tamponade
What is diagnostic of cardiac tamponade
Treatment
Dx - Echocardiogram
Treatments -
Oxygen + ventilation
1-2 L IV fluids
urgent pericardiocentesis
Atrial myxoma
Features
Left atrium 75%
Benign tumour , groves on inter-atrium septum wall
10% inherited
- obstruct mitral valve = mid diastolic murmur , syncope, dyspnoea
- PE stroke clubbing and blue fingers
- AF
Echo : pedunculated heterogenous mass attached to fossa ovalis
Dx?
Atrial myxoma
Axis deviation
Check lead 1 and AVF 1 & AVF - both pointing up = normal 1 up , AVF down - left axis deviation 1 down, AVF up - right axis deviation Both down - right superior axis deviation
Causes of left axis deviation (5)
Inferior MI LVH Left anterior fascicular block or hemi-block Obese WPW
Right axis deviation causes (6)
Lateral MI RVH Left posterior fascicular block or hemiblock Thin tall children Chronic lung disease Pulmonary embolism
Causes of extreme right axis deviation
Congenital heart disease
Left ventricular aneurysm
1st degree heart block + management
PR > .2s only
No treatment as long as pt is asymptomatic
2nd degree heart block + management
- Mobitz 1 = wenkebach
Progressive prolongation of PR until a beat drops - Mobitz 2
Constant PR interval, but P wave often not followed by QRS
Permanent pacemaker
3rd degree heart block + management
No association between P and QRS
Pacemaker
Rate control in AF
B blockers - 1st line , CI in asthma
CCB - (non dihydropyridine )= diltiazem, verapamil - used in asthma
Digoxin - preferred choice if coexistent with heart failure
Unstable - cardio version
Aflutter management
Cardioversion - shock
VTach management
Conscious/ semiconscious hemodynamically stabl e
- Amiodarone
Unstable - DC cardioversion
Vfib management
- defibrillation - asynchronised shock
Symptomatic sinus bradycardia
Treatment
O2 , ABCD
Atropine .5mg IV push , can repeat until 3mg given
If no response - temporary transcutaneous pacemaker
Normal in young athletes
Sinus tachy causes
Excercise, stress, anger
Hx of infection
Treat the cause
CHF management
Symptomatic relief and reduce vol overload - diuretics
= furosemide, lascivious or bumetanide
Start w/ ACEi or BB one at a time, If sx persist and the next one
- start with ACEi if diabetic
If sx still persist - add Spironolactone
CHF on treatment , still has LL oedema
Next step
Up dose of fursemide
Or switch to bumetanide to torsemide
Consider admission for IV loop diuretics
HF + a fib management
Digoxin
Patent foramen ovale
Features
Most accurate investigation
R—>L atrium blood flow
Most individuals - not problematic , undetected
Paradoxical embolism - emb from venous to arterial side
= stroke or TIA
Transoesophageal echo with bubble contrast = gold
Pericarditis
Features
ECG
Within 48 hrs of MI
Pleuritic chest pain , worse lying flat and during inspiration +_ fever, pericardial rub
Confirm via echo
ECG - widespread saddle shaped ST elevation + upward con cavity + PR depression
Treatment pericarditis
Full dose NSAID -
=ibuprofen 100-1800mg/d; indomethacin 75-150mg/d
Aspirin
2-4g/d
=7-14 days
Dressler syndrome
Features , ECG
Pericarditis in 2-6 weeks following MI
Autoimmune reaction against antigenic proteins as myocardium recovers
Same features as pericarditis + raised ESR
Saddle shaped ST elevation +- PR depression
Treatment of Dressler’s syndrome
NSAIDs
Left ventricular aneurysm
Features
XR ECHO ECG
4-6 weeks post MI
Weakened myocardium - thin muscular layer - aneurysm formation
Left ventricle failure + persistent ST elevation
Can increase risk of stroke
ECG - persistent ST elevation + LVF
Bulge at left heart border XR
Echo - paradoxical movement of ventricular wall
VSD
Features
Treatment
1st week after MI in 1-2% patients
Pan systolic murmur + acute heart failure
Echo- diagnostic - excludes MR
Urgent surgical correction
Mitral regurgitation
Pan systolic murmur (early-mid diastolic)
2-15 days after MI
Ischemia or rupture of papillary muscles of mitral valve
Hypotension tachycardia pulmonary oedema
Echo- dx
Treatment - vasodilator therapy and surgical repair
New murmur + fever + malaise and rigours
Dx?
Initial step?
Infective endocarditis
Blood culture —> echo
RF of infective endocarditis
Previous episode of endocarditis = strongest RF
Rheumatic valve disease
Prosthetic valve
Congenital heart defects
IV drug users - typically tricuspid lesion
Causative organism of IE
Staph aureus - general
Epidermis is - after prosthetic valve surgery
Viridans (mitris and sanguidis) - poor dental hygiene or after dental procedure
Modified duke criteria - major
IE 2 major or 1 major 3 minor or 5 minor Major - 1. + blood culture 2, showing HÁČEK or known organism) or persistent bacteremia in 2 cultures >12 hrs apart or 3 or + with staph aureus or epidermidis
2.evidence of endocarditis involvement = echo +ve for IE
Modified duke criteria - minor
- Predisposing heart condition or IVDU
- Microbiological evidence that doesn’t meet major criteria
- Fever >38
- Vascular phenomena
= Jane way , petechia, purpura, splinter hgx, major emboli, splenomegaly - Immunological phenomena
- oiler node, Roth spots, glomerulonephritis
Oiler node vs janeway lesion
O - painful red nodules on hand and feet
J- non tender, small erythematous or hemorhhagic macular or nodular lesions on soles /palms
= septic microemboli
Endocarditis - initial empirical blind therapy
National valve endocarditis -
Amoxicillin + low dose gentamicin or
Vancomycin + low dose gentamicin - ig peicillin allergic or MRSA suspect or sever sepsis
Hx of prosthetic valve
Vancomycin + low dose gentamicin+ rifampin
CHA2DS2VASc score
CHF HTN Age =/>75 = 2pts DM S- prior stroke , TIA, thromboembolism = 2pts Vascular disease Age 65-74 Sex category - female
Score =/> 2 - warfarin or DOAC , men >/=1 - the same
Score to estimate risk of major bleeding inpatients on anti coagulation for atrial fibrillation
HAS BLED score
What score predicts 3 month outcome in ischaemic stroke patients receiving tPA (alteplase)
DRAGON score
What is the QRISK2 score
Determines risk of cardiovascular event in next 10 years
Pulmonary oedema
Features
Desaturation Dyspnoea Orthopnoea Auscultation = crackles /rales Tachycardia Kerley lines on CXR
Most appropriate investigation for pulmonary oedema
CXR
Investigation needed to identify cause of pulmonary oedema
Echo
Management of pulmonary oedema
MONF Morphine O2 Nitrates Furosemide O2 sat >92% or 90 in COPD 2 puffs GTN 40 mg IV furosemide - slow Diamorphine 2/5-5mg IV slowly or morphine 5-10mg IV slow
If heart failure also present : + ACEi or BB one at a time on discharge
Dissecting aortic aneurysm
Clinchers
Unequal pulses upper limb Hx of Marfan Tall long slender limbs and fingers Ehler danlos/ Turner Severe chest pain radiating to back HTN - most important RF
Dissecting aneurysm presentation
Presentation: hypotension, SOF , tachycardia, sweating
Most important risk factor dissecting aneurysm
HTN
Pathophysiology of dissecting aneurysm
Tear in tunica intima wall of aorta
- blood floes between layers of aorta - forces layers apart