Urinary Issues and Men's Health Issues (week 8&9) Flashcards
Name a Cholinergic Muscarinic Agonist
Bethanechol (Urecholine)
What is Bethanechol (Urecholine) used for?
Urinary retention in post op, postpartum
What is the MOA of Bethanechol (Urecholine)?
Activates Muscarininc receptors of the urinary tract.
What are the adverse effects of Bethanchol (Urecholine)?
Hypotension
Bradycardia
Bronchoconstriction
Before administration of Bethanechol (Urecholine), what kind of PMH do you want to be aware of?
Hyperthyroidism
Hypotensive or Bradycardia pt’s
Small bowel or urinary tract obstructions
How should you administer Bethanechol (Urecholine)?
One hour before or after food
Nausea and vomiting will occur if taken with food
What is the reversal agent of Bethanechol (Urecholine)?
Atropine
What are the signs and symptoms of muscarinic poisoning?
Profuse salivation and tearing Bronchospasms Diarrhea Bradycardia Hypotension
Name a Cholinergic M3 Antagonist
Oxybutynin (Ditropan XL)
What is Oxybutynin used for?
Overactive bladder
What is the MOA of Oxybutynin (Ditropan XL)?
Block M receptors of the urinary tract
What are some adverse effects of Oxybutynin (Ditropan XL)?
Meets Beers Criteria
Constipation, blurred vision, photophobia, dry eyes, and dry mouth
Tachycardia if blended into M1 and M2 receptors
What do you want to know before administering Oxybutynin (Ditropan XL)?
Urinary patterns
If someone has Glaucoma and severely decreased gastric motility, what drug can you not give them?
Oxybutynin (Ditropan XL)
What should you advise a patient to do when they are experiencing anticholinergic effects?
Chew gum
Wear sunglasses
Avoid hazardous activity
What is the reversal agent to Oxybutynin (ditropan XL) ?
Physostigmine
What are the two major concerns for mens health?
Erectile Dysfunction
Benign Prostatic Hyperplasia
What class of drugs are used to treat ED?
PDE5 Inhibitors
Name two PDE5 Inhibitors
Sildenafil (Viagra)
Cialis
What is the MOA of PDE5 Inhibitors?
Converst cGMP to GMP
What is the MOA of Sildenafil (Viagra)?
Prevents cGMP from converting to GMP
What is taken for Pulmonary arterial HTN but can also be used for ED?
Revatio
When does Sildenafil (Viagra) peak?
60 min on an empty stomach of 2 hours after high fat meal
What are some adverse effects of Sildenafil (Viagra)?
Hypotension in men taking Nitrates
Priapism (erection lasting over 6 hours)
Sudden hearing loss
Sudden vision loss
When you should you take Viagra?
Once daily one hour before sexual activity
What drug is given daily regardless of sexual activity?
Tadelafil (Cialis)
What are the two approaches of BPH?
Mechanical (Overgrowth of epithelial cells)
Dynamic (Overgrowth of smooth muscle cells)
Name a 5 -Alpha-Reductase Inhibitor
Finasteride (Proscar)
What is Finasteride (Proscar) used for?
Enlarged prostate
What is the MOA of Finasteride (Proscar)?
Promotes regression of prostate epithelial tissue
Who should not take e Finasteride (Proscar)?
Pregnant women or those who may become pregnant
If the PSA is constantly increasing, what does this indicate?
Prostate cancer
Name an Alpha1-Adrenergic Antagonist
Tamsulosin (Flomax)
What is Tamsulosin (Flomax) used for?
Mild prostatic enlargement but still having issues urinating
What is the MOA of Tamsulosin (Flomax)?
Selective blockage of Alpha1 receptors relaxes smooth muscle in bladder neck and prostate
What drug should be taken life long?
Tamsulosin (Flomax)
