Anti-Viral Agents - Non-HIV (Week 10) Flashcards
What are the infections that drugs for non-HIV infections are used for?
Herpes Virus
Influenza
Antiretrovials
What is Acyclovir used for?
Recurrent genital herpes infections
Is Acyclovir curative?
No, its not a curative, only shortens duration
What is the MOA of Acyclovir?
Interferes with viral DNA synthesis
What are some common adverse effects of Acyclovir?
Dizziness
Headache
Diarrhea
Phlebitis
What are some serious adverse effects of Acyclovir?
Reversible Nephrotoxicity
What do you need to know before administering Acyclovir?
PMH of dehydration, renal impairment, taking nephrotoxicdrugs
How is Acyclovir administered?
Oral - with or without food
IV - Slow infusion
Topical - apply the drug with a rubber glove
What should you emphasize to a patient who is taking Acyclovir?
This is not a cure and the importance of preventing spread with sexual contact.
What drug do you use to treat influenza?
Neuraminidase Inhibitor: Oseltamivir (Tamiflu)
What is Oseltaminir (Tamiflu) used for?
Adults and children 1 year or OLDER who have contracted influenza A or B
How is Oseltamivir (Tamiflu) given?
PO no later than 2 days after the onset of symptoms
What is the MOA of Oseltamivir (Tamiflu)?
Inhibits the viral enzyme neuraminidase thereby preventing the virus from exiting the cell wall
What is a contraindication of Oseltamivir?
Children less than 1 year old
What is a precaution of Oseltamivir?
Lactation
