PUD Drugs (week 8&9)

Question 1

What are the 3 goals of treatment for PUD?

Answer 1

Alleviate symptoms
Promote healing
Prevent complications

Question 2

What is the only thing that can cure PUD?

Answer 2

Antibiotics

Question 3

What are the 5 classes of Anti-Ulcer Drugs?

Answer 3

Antibiotics
Antisecretory agents (Proton-pump inhibitors)
Mucosal protectants
Antisecretory agents that enhance mucosal defenses
Antacids

Question 4

What are the Antibiotics that cure H. pylori?

Answer 4

Amoxicillin
Clarithromycin
Omeprazole

Question 5

What are the two anti secretory agents?

Answer 5

H2-Receptor Antagonists (Cimetidine)

Proton-Pump Inhibitors (Omeprazole)

Question 6

What is one mucosal protectants?

Answer 6

Sucralfate

Question 7

What is an anti secretory agents that enhances mucosal defenses?

Answer 7

Prostaglandin Analog (Misoprostol)

Question 8

What are two Antacids?

Answer 8

Aluminum hydroxide

Magnesium hydroxide

Question 9

Can ulcers due to H. Pylori be cured?

Answer 9

Yes

Question 10

What is Clarithromycin and Amoxicillin considered?

Answer 10

The first line of defense for H. Pylori

Question 11

What is the best therapy combination for H. Pylori?

Answer 11

Clarithromycin, Amoxicillin, and a PPI

Question 12

Name 3 H2 Receptor Antagonists.

Answer 12

Cimetidine
Famotidine
Ranitidine

Question 13

What does Cimitidine (Tagamet) treat?

Answer 13

Gastric and Duodenal Ulcers

GERD

Question 14

What is the MOA of Cimitidine (Tagamet)?

Answer 14

Blocks H2 receptors on parietal cells to decrease acid production.

Question 15

What are some serious concequences of Cimetidine (Tagamet)?

Answer 15

Pneumonia due to lowered pH

Antiandrogenic affects

Question 16

What affects absorption for Cimetidine?

Answer 16

Antacids

Question 17

How is Cimetidine (Tagamet) administered?

Answer 17

IV Push

Question 18

What do you want to encourage patients to limit when taking Cimetidine?

Answer 18

Factors that contribute to PUD

Question 19

What is more effective than H2 Blockers?

Answer 19

Omeprazole (Prilosec)

Question 20

What is Omeprazole (Prilosec) used to treat?

Answer 20

GERD

Question 21

What are serious adverse effects of Omeprazole (Prilosec)?

Answer 21

Pneumonia
Fractures due to low calcium
Risk for electrolyte issues
Rebound Acid Hypersecretion

Question 22

What drug does Omeprazole interact with?

Answer 22

Clopidogrel

Certain HIV drugs

Question 23

What kind of dosing should you use when taking Omeprazole?

Answer 23

Take the lowest dose for the shortest period of time if possible

Question 24

What should you educate a patient about while taking Omeprazole?

Answer 24

S/S of hypomagnesemia

Question 25

What are some other Antiulccer drugs?

Answer 25

Sucralfate (Carafate)

Misoprostol (Cytotec)

Question 26

What is Sucralfate (Carafate) used for?

Answer 26

Duodenal ulcers

Question 27

What is the MOA of Sulcrafate (Carafate)?

Answer 27

Adheres to ulcer crater and coats it

Question 28

What is Misoprostol (Cytotec) used for?

Answer 28

Ulcers due to NSAID use

Question 29

What is an adverse effect of Misoprostol (Cytotec)?

Answer 29

Pregnancy - Cat X (Stimulates uterine contractions)

Question 30

Does Aluminum Hydroxide cause constipation or diarrhea?

Answer 30

Constipation

Question 31

Does Magnesium hydroxide cause constipation or diarrhea?

Answer 31

Diarrhea

Question 32

Does Calcium Carbonate cause constipation or diarrhea?

Answer 32

Constipation

Question 33

What is sodium bicarbonate used to treat?

Answer 33

Acidosis and to alkalinize urine