PUD Drugs (week 8&9) Flashcards
What are the 3 goals of treatment for PUD?
Alleviate symptoms
Promote healing
Prevent complications
What is the only thing that can cure PUD?
Antibiotics
What are the 5 classes of Anti-Ulcer Drugs?
Antibiotics
Antisecretory agents (Proton-pump inhibitors)
Mucosal protectants
Antisecretory agents that enhance mucosal defenses
Antacids
What are the Antibiotics that cure H. pylori?
Amoxicillin
Clarithromycin
Omeprazole
What are the two anti secretory agents?
H2-Receptor Antagonists (Cimetidine)
Proton-Pump Inhibitors (Omeprazole)
What is one mucosal protectants?
Sucralfate
What is an anti secretory agents that enhances mucosal defenses?
Prostaglandin Analog (Misoprostol)
What are two Antacids?
Aluminum hydroxide
Magnesium hydroxide
Can ulcers due to H. Pylori be cured?
Yes
What is Clarithromycin and Amoxicillin considered?
The first line of defense for H. Pylori
What is the best therapy combination for H. Pylori?
Clarithromycin, Amoxicillin, and a PPI
Name 3 H2 Receptor Antagonists.
Cimetidine
Famotidine
Ranitidine
What does Cimitidine (Tagamet) treat?
Gastric and Duodenal Ulcers
GERD
What is the MOA of Cimitidine (Tagamet)?
Blocks H2 receptors on parietal cells to decrease acid production.
What are some serious concequences of Cimetidine (Tagamet)?
Pneumonia due to lowered pH
Antiandrogenic affects
What affects absorption for Cimetidine?
Antacids
How is Cimetidine (Tagamet) administered?
IV Push
What do you want to encourage patients to limit when taking Cimetidine?
Factors that contribute to PUD
What is more effective than H2 Blockers?
Omeprazole (Prilosec)
What is Omeprazole (Prilosec) used to treat?
GERD
What are serious adverse effects of Omeprazole (Prilosec)?
Pneumonia
Fractures due to low calcium
Risk for electrolyte issues
Rebound Acid Hypersecretion
What drug does Omeprazole interact with?
Clopidogrel
Certain HIV drugs
What kind of dosing should you use when taking Omeprazole?
Take the lowest dose for the shortest period of time if possible
What should you educate a patient about while taking Omeprazole?
S/S of hypomagnesemia
What are some other Antiulccer drugs?
Sucralfate (Carafate)
Misoprostol (Cytotec)
What is Sucralfate (Carafate) used for?
Duodenal ulcers
What is the MOA of Sulcrafate (Carafate)?
Adheres to ulcer crater and coats it
What is Misoprostol (Cytotec) used for?
Ulcers due to NSAID use
What is an adverse effect of Misoprostol (Cytotec)?
Pregnancy - Cat X (Stimulates uterine contractions)
Does Aluminum Hydroxide cause constipation or diarrhea?
Constipation
Does Magnesium hydroxide cause constipation or diarrhea?
Diarrhea
Does Calcium Carbonate cause constipation or diarrhea?
Constipation
What is sodium bicarbonate used to treat?
Acidosis and to alkalinize urine
