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Pharm Test 3 > Anti-Diarrheals (week 8&9) > Flashcards

Anti-Diarrheals (week 8&9) Flashcards

1
Q

What are anti-diarrheal used for?

A

Gi Disease - infection, inflammation, maldigestion

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2
Q

What are the two major groups of antidiarrheals?

A

Specific

Nonspecific

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3
Q

What are two nonspecific antidiarrheal agents?

A

Opioids

Diphenoxylate with Atropine

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4
Q

What is the biggest complain of Opioids?

A

Constipation

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5
Q

What is the most effective antidiarrheal agent?

A

Opioids

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6
Q

What are the three prototypes of opioids?

A

Tincture of Opium
Diphenoxylate with Atropine (Lomotil)
Loperamide (Imodium)

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7
Q

What are the MOA of Opioids?

A

Activate opioid receptors in GI tract?

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8
Q

Why is Atropine added to Diphenoxylate?

A

to prevent abse and anti-cholinergic effects

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9
Q

What opioid was little or no potential for abuse?

A

Loperamide

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10
Q

What are the specific anti-diarrheals?

A

Antibiotics

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11
Q

What are two examples of IBD?

A

Crohns disease

Ulcerative Colitis

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12
Q

What are the charactoristics of IBS?

A

Crampy abdominal pain
Diarrhea
Constipation

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13
Q

What is IBS-M?

A

Irritable Bowel Syndrome Mixed (Constipation and Diarrhea)

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14
Q

What are the two categories of drugs for IBS?

A

Nonspecific

Specific

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15
Q

Name some Nonspecific drugs for IBS

A

Antispasmodics
Bulk-forming agents
Antidiarrheals
Tricyclic Antidepressants (TCA)

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16
Q

Name a Specific IBS drug

A

Alosetron (Setron - Serotonin)

17
Q

What is the MOA of Alosetron?

A

Selective blockade of 5-HT3 receptors

18
Q

What are the adverse effects of Alosetron?

A

Constipation

19
Q

What are the drugs used to control IBD?

A 
5-Aminosalicylates 
Glucocorticoids 
Immunosuppressants 
Immunomodulators 
Antibiotics
20
Q

What is the focus of care for IBD?

A

Antibiotics
Anti-inflammatory
Immunosuppressants

21
Q

Name a Prokinetic Agent

A

Metoclopramide (Reglan)

22
Q

What is the use of Metoclopramide (Replan) when taken orally?

A

Diabetic Gastroparesis

GERD

23
Q

What is the use of Metoclopramide (Replan) when given IV?

A

N/V

Difficult NG Placement

24
Q

What is the MOA of Metoclopramide (Replan) When taken for emesis?

A

Blocks receptors for dopamine and serotonin in the CTZ

25
Q

What is the MOA of Metoclopramide (Reglan) when taken for slowed GI motility?

A

Enhances the actions of acetylcholine

26
Q

What are the long term effects of Metoclopramide (Reglan)?

A

Irreversible tardive dyskinesia

Pharm Test 3 (15 decks)

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