Migraines

Question 1

____ is a neuromuscular disorder involving dilation and inflammation of intracranial arteries.

Answer 1

Migraines

Question 2

Name the two prototypes used for migraines

Answer 2

Ergots

Triptons

Question 3

What is the MOA of Ergots?

Answer 3

Block inflammation associated with the trigeminal vascular system.

Question 4

What is the MOA of Triptons?

Answer 4

Vasoconstriction of dilated blood vessels by stimulating 5-HT receptors

Question 5

Are Ergots and Triptons used for Prophylaxis?

Answer 5

No, they are only used when you already have a migraine

Question 6

What is the first line of defense for migraines?

Answer 6

Triptons

Question 7

Can you take Triptons and Ergots at the same time?

Answer 7

No

Question 8

What will happen is you take Ergots or Triptons with SSRI’s/SNRI’s?

Answer 8

Serotonin syndrome

Question 9

What do you want to know about someones PMH before administering Triptons?

Answer 9

Ischemic heart disease
Prior MI
Uncontrolled HTN
Pregnancy

Question 10

What do you want to know about someones PMH before administering Ergots?

Answer 10

Hepatic or renal impairment
Sepsis
CAD
PVD
Pregnany

Question 11

What can you develop while taking ergots that results in muscle pain, paresthesias, and cold extremities?

Answer 11

Ergotism