Urinary Flashcards
What is the normal pH of urine?
7.5-8.5
What urinary biochemical can be used to identify proximal tubular necrosis?
GGT
Which Leptopsira has been assocaited with anaemia and haemoglobinuria
L. iterrogans Pomona
Which virus (also assocaited with respiratory dz) has been a rarely reported cause of cortical interstitial nephritis?
Adenovirus
Describe the pathology seen with lamb nephrosis
Large, pale, soft kidneys. Protein losing nephropathy. Hyalin casts. Focal glomerular necrosis.
List 5 broad categories of renal toxins
Oxalates
Tannins
Heavy metals
Vitamin D
Ethylene glycol
List 4 oxalate containing plants
Dock, sorrel, beet leaves, rhubarb
List two plants with toxic levels of vitamin D
Jasmine, nightshades
List six heavy metals associated with renal toxicity
Copper, Zinc, Lead, Mercury, Cadmium, Arsenic
Give a ballpark figure for toxic copper dose in sheep (much variation)
20ppm
What copper:molybdenum ratio is reported as high risk for toxicity
> 10:1
Explain the pathophysiology of copper toxicity
Excess copper is stored in the lysosomes of the liver. It is acutely released during stress. This oxidises haemoglobin to methaemoglobin. Oxidative stress triggers red blood cell lysis.
In which kidney is pyelonephritis more common?
Left (shorter ureter)
What bacteria is the most common cause of pyelonephritis? How does urinary acidification help to treat?
Corynebacterium renale. Acidification prevents pili adhering
What are the two generak causes of renal amyloidosis
Chronic inflammation (amyloid A), myeloma (amyloid L)