Upper GI Pharmacology

Question 1

L2: Name two proton pump inhibitors

Answer 1

Omeprazole, Lansoprazole

Question 2

L2: Which pharmacologic agent(s)? AChEI used in motility disorders

Answer 2

Neostigmine

Question 3

L2: Which pharmacologic agent(s)? Agonist at excitatory 5HT-4 receptors on ENS motor neurons

Answer 3

Cisapride

Question 4

L2: Which pharmacologic agent(s)? Agonist at excitatory M3 smooth muscle receptors

Answer 4

Bethanechol

Question 5

L2: Which pharmacologic agent(s)? Agonist at excitatory neural and smooth muscle motilin receptors

Answer 5

Erythromycin

Question 6

L2: Which pharmacologic agent(s)? Antacids that cause constipation

Answer 6

Mg

Question 7

L2: Which pharmacologic agent(s)? Antacids that cause diarrhea

Answer 7

Ca, Al

Question 8

L2: Which pharmacologic agent(s)? Antacids usually avoided due to systemic side effects

Answer 8

Bicarbonate

Question 9

L2: Which pharmacologic agent(s)? Antagonist at presynaptic inhibitory dopamine neurons in ENS

Answer 9

Metoclopramide

Question 10

L2: Which pharmacologic agent(s)? Better at blocking nocturnal acid secretion than meal-induced acid secretion

Answer 10

H2 antagonist

Question 11

L2: Which pharmacologic agent(s)? Binds to necrotic ulcer tissue to form a protective barrier

Answer 11

Sucralfate

Question 12

L2: Which pharmacologic agent(s)? Covalent linkage of drug to H/K ATPase, causing irreversible inactivation

Answer 12

PPI

Question 13

L2: Which pharmacologic agent(s)? Formerly used as adjunct to H2 blockers to decrease acid secretion in refractory patients

Answer 13

Anticholinergic agents

Question 14

L2: Which pharmacologic agent(s)? Maximum acid suppression may require 2-5 days

Answer 14

PPI

Question 15

L2: Which pharmacologic agent(s)? May inhibit conversion of clopidogrel to active form, increasing risk of clotting

Answer 15

Omeprazole

Question 16

L2: Which pharmacologic agent(s)? Prokinetic agent used only in IBS with restrictions due to increased risk of heart attacks, stroke, and unstable angina

Answer 16

Tegaserod

Question 17

L2: Which pharmacologic agent(s)? Prokinetic agent with side effect of increased risk of arrhythmias secondary to QT prolongation

Answer 17

Cisapride

Question 18

L2: Which pharmacologic agent(s)? Prokinetic agent with side effect of increased risk of tardive dyskinesia

Answer 18

Metoclopramide

Question 19

L2: Which pharmacologic agent(s)? Prokinetic agents that do not increase GI muscle contractions in a coordinated manner

Answer 19

Bethanechol, Neostigmine

Question 20

L2: Which pharmacologic agent(s)? Prostaglandin analog that decreases proton secretion and increases bicarbonate secretion in protective mucus

Answer 20

Misoprostol

Question 21

L2: Which pharmacologic agent(s)? Rapidly increase pH to 4.5 to decrease action of pepsin

Answer 21

Antacids

Question 22

L2: Which pharmacologic agent(s)? Rebound increases in gastric acidity may occur following discontinuation

Answer 22

PPI

Question 23

L2: Which pharmacologic agent(s)? Reversible, competitive block at parietal cell receptors on the basolateral membrane

Answer 23

H2 antagonist

Question 24

L2: Which pharmacologic agent(s)? Side effect of blood dyscrasias rarely

Answer 24

H2 antagonists

Question 25

L2: Which pharmacologic agent(s)? Side effects of gynecomastia, galactorrhea, and decreased sperm count

Answer 25

Cimetidine

Question 26

L3: Name the components of Triple therapy for H pylori infection

Answer 26

PPI + Clarithromycin/Amoxicillin + Metronidazole

Question 27

L4: Name four H2 receptor antagonists

Answer 27

Ranitidine, Cimetidine, Famotidine, Nizatidine

Question 28

L4: Name the components of Quadruple therapy for H pylori infection

Answer 28

PPI + Bismuth + Metronidazole + Tetracycline