Stomach Flashcards

1
Q

L1: What feature of H. pylori enables its resistance to gastric acid?

A

Urease

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2
Q

L1: Which pathologic pattern? Most common bacterial infection of the stomach

A

Helicobacter pylori

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3
Q

L2: Name the two types of gross morphology for gastric carcinoma.

A

Linitis plastica and ulcerating

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4
Q

L2: Name the two types of microscopic morphology for gastric carcinoma.

A

Intestinal type and diffuse type

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5
Q

L2: Name two virulence factors associated with H pylori infection

A

VacA, CagA

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6
Q

L2: What is the characteristic histologic features of diffuse type gastric carcinoma?

A

Signet ring cells

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7
Q

L2: What is the most common gene class involved in GIST tumors?

A

Tyrosine Kinases

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8
Q

L2: What is the most common molecular aberration in diffuse type gastric carcinoma?

A

CDH1 mutation/methylation

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9
Q

L2: What is the most common molecular aberration in intestinal type gastric carcinoma?

A

Wnt/APC mutation

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10
Q

L2: What is the treatment for MALT lymphoma?

A

H. pylori treatment/eradication

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11
Q

L2: What is the treatment? Hyperplasia of pyloric muscularis propria causing obstruction of gastric flow

A

Surgical Myotomy

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12
Q

L2: What pathologic pattern? Associated with c-kit mutaiton

A

GIST

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13
Q

L2: What pathologic pattern? Causes persistent non-bilious projectile vomiting in young infants

A

Infantile Hypertrophic Pyloric Stenosis

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14
Q

L2: What pathologic pattern? Thickening of the wall in the context of gastric carcinoma

A

Linitis plastica pattern

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15
Q

L2: What pathologic pattern? Ulcers with heaped up edges and unclean bases

A

Adenocarcinoma

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16
Q

L2: Which pathologic pattern? Associated with prostaglandin depletion and reduced mucus production

A

NSAID-induced gastritis

17
Q

L2: Which pathologic pattern? Autoimmune attack against parietal cells producing Intrinsic Factor

A

Autoimmune Gastritis

18
Q

L2: Which pathologic pattern? Classically seen in patients with mechanical ventilation, CNS injury, a coagulopathy, or burns

A

Stress-Related Mucosal Injury

19
Q

L2: Which type of gastric polyp appears grossly as bumps on the stomach wall with microscopic dilatation of glands?

A

Fundic gland polyp

20
Q

L2: Which type of gastric polyp has dark atypical cells with dysplasia on microscopic analysis?

A

Gastric adenoma

21
Q

L2: Which type of gastric polyp is associated with chronic PPI use?

A

Fundic gland polyp

22
Q

L2: Which type of gastric polyp is associated with FAP?

A

Gastric adenoma

23
Q

L2: Which type of gastric polyp is benign and develops in response to chronic gastritis?

A

Hyperplastic polyp

24
Q

L2: Which type of gastric polyp is large, pedunculated and found predominantly in the stomach and antrum of the stomach?

A

Hyperplastic polyp

25
Q

L2: Which type of gastric polyp is most common?

A

Hyperplastic polyp

26
Q

L3: Indications (3) for H. pylori treatment

A

peptic ulcers, gastric lymphoma, family hx of gastric carcinoma

27
Q

L3: Name the 3 complications of peptic ulcer disease in order of decreasing incidence

A

Bleeding, Perforation, Obstruction

28
Q

L3: Name the three types of gastric polyps. Which has a greater likelihood of progression to malignancy?

A

Hyperplastic, gastric adenoma, fundic gland polyp; gastric adenoma

29
Q

L3: Name the two most common diagnostic tests for H. pylori infection

A

Rapid urease; endoscopy with mucosal biopsy

30
Q

L3: What is the gross appearance of ulcers in peptic ulcer disease?

A

Punched-out ulcer with a clean base

31
Q

L4: Name 4 sequelae of H. pylori infection

A

peptic ulcers, atrophic gastritis, gastric cancer, lymphoma

32
Q

L4: Name the 4 most common gastric neoplasms.

A

Adenocarcinoma, Gastric Polyp, GIST, Carcinoid tumor, MALT lymphoma

33
Q

L4: Name the components of H. pylori quadruple therapy

A

PPI, metronidazole, tetracycline, bismuth

34
Q

L4: Name the components of H. pylori triple therapy

A

PPI, amoxicillin, clarithromycin