Stomach Flashcards
L1: What feature of H. pylori enables its resistance to gastric acid?
Urease
L1: Which pathologic pattern? Most common bacterial infection of the stomach
Helicobacter pylori
L2: Name the two types of gross morphology for gastric carcinoma.
Linitis plastica and ulcerating
L2: Name the two types of microscopic morphology for gastric carcinoma.
Intestinal type and diffuse type
L2: Name two virulence factors associated with H pylori infection
VacA, CagA
L2: What is the characteristic histologic features of diffuse type gastric carcinoma?
Signet ring cells
L2: What is the most common gene class involved in GIST tumors?
Tyrosine Kinases
L2: What is the most common molecular aberration in diffuse type gastric carcinoma?
CDH1 mutation/methylation
L2: What is the most common molecular aberration in intestinal type gastric carcinoma?
Wnt/APC mutation
L2: What is the treatment for MALT lymphoma?
H. pylori treatment/eradication
L2: What is the treatment? Hyperplasia of pyloric muscularis propria causing obstruction of gastric flow
Surgical Myotomy
L2: What pathologic pattern? Associated with c-kit mutaiton
GIST
L2: What pathologic pattern? Causes persistent non-bilious projectile vomiting in young infants
Infantile Hypertrophic Pyloric Stenosis
L2: What pathologic pattern? Thickening of the wall in the context of gastric carcinoma
Linitis plastica pattern
L2: What pathologic pattern? Ulcers with heaped up edges and unclean bases
Adenocarcinoma