Unit 2 - Parasitism Flashcards

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1
Q

What is a ecological niche?

A

An ecological niche is a multi-dimensional
summary of tolerances and requirements of a
species

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2
Q

What is a fundamental niche?

A

A species has a fundamental niche that it
occupies in the absence of any interspecific
competition

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3
Q

What is a realised niche?

A

A realised niche is occupied in response to
interspecific competition

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4
Q

What is competitive exclusion?

A

where the niches of two species are so similar that one declines to local extinction

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5
Q

What is resource partitioning?

A

Where the realised niches are sufficiently
different, potential competitors can co-exist
by resource partitioning

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6
Q

What is paratitism?

A

Parasitism is a symbiotic interaction between
a parasite and its host (+/-). A parasite gains benefit in terms of nutrients
at the expense of its host

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7
Q

What is the difference in the reproductive potential of the host to parasitise?

A

Unlike in a predator–prey relationship, the
reproductive potential of the parasite is
greater than that of the host.

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8
Q

What do parasites have?

A

a narrow (specialised)
niche as they are very host-specific

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9
Q

What does degenerate mean?

A

lacking structures and organs found in other organisms

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10
Q

What does the host provide?

A

As the host provides so many of the
parasite’s needs, many parasites are
degenerate, lacking structures and organs
found in other organisms

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11
Q

What is an ectoparasite?

A

An ectoparasite lives on the surface of its
host,

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12
Q

What is an endoparasite?

A

lives within the tissues of its host

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13
Q

What is the definitive host?

A

The definitive host is the organism on or in
which the parasite reaches sexual maturity.
Intermediate hosts may also be required for
the parasite to complete its life cycle

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14
Q

What is a vector?

A

A vector plays an active role in the
transmission of the parasite and may also be
a host

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15
Q

What is the life cycle of Plasmodium?

A
  • An infected mosquito, acting as a vector,
    bites a human.
  • Plasmodium enters the human bloodstream.
  • Asexual reproduction occurs in the liver and then in the red blood cells.
  • When the red blood cells burst gametocytes are released into the bloodstream.
  • Another mosquito bites an infected human and the gametocytes enter the mosquito, maturing into male and female gametes, allowing sexual reproduction to now occur.
  • The mosquito can then infect another human host
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16
Q

What is the life cycle of Schistosomes?

A
  • Schistosomes reproduce sexually in the human intestine.
  • The fertilised eggs pass out via faeces into water where they develop into larvae.
  • The larvae then infect water snails, where asexual reproduction occurs.
  • This produces another type of motile larvae, which escape the snail and penetrate the skin of a human, entering the bloodstream.
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17
Q

What is the definitive host in plasmodium?

A

In the mosquito

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18
Q

What is the intermediate host in plasmodium?

A

Human where asexual reproduction takes place

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19
Q

What is the definitive host of the schistosomes?

A

Human

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20
Q

What is the intermediate host of the schistosomes?

A

Snail

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21
Q

What are viruses?

A

Viruses are parasites that can only replicate
inside a host cell

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22
Q

What do viruses contain?

A

Viruses contain genetic material in the form
of DNA or RNA, packaged in a protective
protein coat

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23
Q

What are viruses surrounded by?

A

Some viruses are surrounded by a
phospholipid membrane derived from host
cell materials

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24
Q

What does the outer surface of a virus contain?

A

The outer surface of a virus contains
antigens that a host cell may or may not be
able to detect as foreign

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25
Q

What is the viral life cycle stages?

A
  • Infection of host cell with genetic material
  • host cell enzymes replicate viral genome
  • transcription of viral genes
  • translation of viral proteins
  • assembly and release of new viral particles
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26
Q

What is RNA retroviruses?

A

RNA retroviruses use the enzyme reverse
transcriptase to form DNA, which is then
inserted into the genome of the host cell

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27
Q

What can viral genes do?

A

Viral genes can then be expressed to form
new viral particles

28
Q

What is transmission?

A

Transmission is the spread of a parasite to a
host

29
Q

What is virulence?

A

Virulence is the harm caused to a host
species by a parasite

30
Q

How are ectoparasites transmitted?

A

through direct contact

31
Q

How are endoparasites transmitted?

A

Endoparasites of the body tissues are often
transmitted by vectors or by consumption of
intermediate hosts

32
Q

What are the factors that increase transmission rates?

A
  • the overcrowding of hosts when they are
    at high density
  • mechanisms, such as vectors and
    waterborne dispersal stages, that allow
    the parasite to spread even if infected
    hosts are incapacitated
33
Q

Why are host behaviours exploited?

A

exploited and
modified by parasites to maximise
transmission

34
Q

What does the host behaviour become?

A

The host behaviour becomes part of the
extended phenotype of the parasite

35
Q

How are host behaviours altered?

A
  • host foraging
  • movement,
  • sexual behaviour
  • habitat choice
  • anti-predator behaviour.
36
Q

What can parasites do to supress the host immune system?

A
  • Modify host size
  • Modify reproductive rate (benefit the
    parasite growth, reproduction or transmission)
37
Q

What do defence against pathogens do humans have?

A

nonspecific and specific aspects

38
Q

What are the non-specific defences?

A

Physical barriers, chemical secretions,
inflammatory response, phagocytes, and
natural killer cells

39
Q

What are natural killer cells?

A

natural killer cells destroying cells infected
with viruses

40
Q

What does the epithelial tissue do?

A

Epithelial tissue blocks the entry of parasites;

41
Q

What do chemical secretions do?

A
  • hydrolytic enzymes in mucus, saliva and
    tears destroy bacterial cell walls;
  • low pH environments of the secretions of stomach,
    vagina and sweat glands denatures cellular
    proteins of pathogens.
42
Q

What happens when cells are injured?

A

Injured cells release signalling molecules. This results in enhanced blood flow to the site, bringing antimicrobial proteins and phagocytes.

43
Q

What is the process of phagocytosis?

A

Killing of parasites using powerful enzymes contained in lysosomes, by engulfing them and storing them inside a vacuole in the process of phagocytosis

44
Q

What do natural killer cells do?

A

Natural killer cells can identify and attach to
cells infected with viruses, releasing
chemicals that lead to cell death by inducing
apoptosis.

45
Q

What are the specific defences?

A

A range of white blood cells constantly
circulate, monitoring the tissues

46
Q

What happens if a tissue becomes damaged or invaded?

A

cells release cytokines that increase blood flow
resulting in non-specific and specific white
blood cells accumulating at the site of
infection or tissue damage

47
Q

What do different lymphocytes have?

A

each possessing a receptor on
its surface, which can potentially recognise a
parasite antigen

48
Q

What happens when an antigen binds to a lymphocytes receptor?

A

lymphocyte’s receptor selects that lymphocyte to then
divide and produce a clonal population of this
lymphocyte

49
Q

What are the two types of things lymphocytes can do?

A
  • Some selected lymphocytes will produce
    antibodies
  • others can induce apoptosis in parasite-infected cells
50
Q

What do antibodies possess?

A

regions where the amino acid sequence varies greatly between different antibodies

51
Q

What does the variable region do?

A

gives the antibody its
specificity for binding antigen

52
Q

What happens when an antigen binds to the binding site?

A

the antigen-antibody complex formed can
result in inactivation of the parasite, rendering
it susceptible to a phagocyte, or can
stimulate a response that results in cell lysis

53
Q

What do memory lymphocyte cells do?

A
  • can produce a secondary response when the
    same antigen enters the body in the future.
  • When this occurs antibody production is enhanced in terms of speed of production, concentration in blood and duration.
54
Q

What do endoparasites do to evade the immune system?

A
  • mimic host antigens to evade detection and modify host immune response to reduce their chances of destruction
  • It may also allow re-infection of the same host with the new variant
55
Q

How do some viruses escape immune surveillance?

A
  • by integrating their genome into host
    genomes,
  • existing in an inactive state known as latency.
  • The virus becomes active again when
    favourable conditions arise
56
Q

What is epidemiology?

A

Epidemiology is the study of the outbreak
and spread of infectious disease

57
Q

What is herd immunity threshold?

A

The herd immunity threshold is the density of
resistant hosts in the population required to
prevent an epidemic

58
Q

What do vaccines contain?

A

Vaccines contain antigens that will elicit an
immune response

59
Q

What makes it difficult to find drugs that only target the parasite?

A

The similarities between host and parasite
metabolism

60
Q

What must be reflected in vaccines?

A

Antigenic variation has to be reflected in the
design of vaccines

61
Q

Why is it often difficult to design vaccines?

A

Some parasites are difficult to culture in the
laboratory making it difficult to design
vaccines

62
Q

What are some of the challenges with parasites spreading?

A
  • overcrowding or tropical climates
  • Overcrowding can occur in refugee camps
    that result from war or natural disaster or
    rapidly growing cities in LEDCs.
63
Q

How do you reduce the rates of transmission?

A
  • Civil engineering projects to improve
    sanitation combined with co-ordinated vector
    control may often be the only practical control
    strategies
  • Improvements in parasite control reduce child
    mortality and result in population-wide
    improvements in child development and
    intelligence, as individuals have more
    resources for growth and development
64
Q

What happens when secondary exposure occurs?

A

When this occurs antibody production is enhanced in terms of speed of production, concentration in blood and duration

65
Q

How are memory cells formed?

A

Initial antigen exposure produces memory
lymphocyte cells specific for that antigen