Unit 2 - Cell Interactions - Mar 13 Flashcards
Basement Membrane (basal lamina)
most abundant of animal cell ECM which underlies (under) epithelial tissue
Extracellular Matrix (ECM) and order(top-bot)?
Material produced by cells that becomes a non-living part of the surrounding tissue, influences cell shape and gene expression. (Essentially what’s left over after you decellularize a tissue)
1.Epithelial tissue
2.connective tissue
Interstitial matrix of connective tissue
underlies basement membrane and makes up bulk of connective tissue
What is the Skin?
community of cells containing 2 main layers: the epidermis and dermis (beneath)
The Epidermis
several layers thick and is an epithelial tissue, mainly keratinocytes but also melanocytes
The Dermis
- made of connective tissue
- contains nerve endings and blood vessels
- is strong and flexible
- consists of mostly fibroblasts which synthesize extracellular matrix and repair wounds
Connective Tissue
a tissue type characterized by few cells and substantial amounts of extracellular matrix (ECM)
Epithelial Cells
cells arranged in 1+ layers and create epithelial tissue
Integrins
integral membrane proteins that help cells actively adhere to ECM
Cadherin
integral membrane protein that help cells adhere to one another
Cell-cell interaction purposes by Junctional Complexes
macromolecular, mediates cell-cell interactions’ many purposes which include Adhesion Junctions, Occluding Junctions, Channel-Forming Junctions.
Adhesion Junctions
cells stick to one another and to ECM to form tissue
Occluding Junctions
prevent passage of hydrophilic solutes from one side of cell layer to other
Channel Forming Junctions
sharing small molecules in cytosol; makes cell signaling faster for temporary tissue cell activity coordination
Tight Junctions
an occluding junction that seals cells together (like zip lock to create a barrier)