Ulcer Drugs

Question 1

Antacids

Answer 1

NaBicarbonate, Mg is a laxative and Al is a constipator, given together to avoid side effects. Decreased acidity affects pepsin and may impair protein digestion.

Question 2

H2 blockers

Answer 2

Block histamine receptors

Question 3

M3 Blockers

Answer 3

Block muscarine receptors.

Question 4

PPIs

Answer 4

Proton pump inhibitors inhibit proton pumps in parietal cells (first enter cell and close pump from the inside). Decreased intrinsic factor leads to a decreased vitB12 absorption. Leads to G cell hypertrophy, D cell atrophy and ECL cell hypertrophy, sudden stopping of treatment may result in acid over-secretion.

Question 5

Prostaglandin analogue

Answer 5

Increases mucosal secretions, decreases acid secretions. Is teratogenic.

Question 6

Sucralfate

Answer 6

Binds the ulcer to protect it from the acidic environment. Sequesters pepsin and other medications.

Question 7

PPIs + anti-H. Pylori antibodies

Answer 7

PPIs and antibodies help against H. Pylori if it is suspected to be an infection.

Question 8

Name 7 drugs to treat ulcers

Answer 8

Antacids, H2 blockers, M3 blockers, PPIs, prostaglandin analogues, sucralfate, PPIs + anti H pylori antibodies.