Antiemetics (Vomiting Drugs)

Question 1

H1 antagonists

Answer 1

Block the higher cortical areas that stimulate the vomiting center. Used to treat morion sickness. SE: headache, sedation, antimuscarine effects.

Question 2

M1 antagonists

Answer 2

Inhibit the CTZ, used to treat motion sickness. SE: blurred vision, sedation.

Question 3

Dopamine receptor 2 antagonists

Answer 3

Inhibit the vestibular nuclei, used following chemotherapy or surgery. SE: parkinsonism, dystonia (involuntary muscle contraction)

Question 4

Serotonin receptor antagonists

Answer 4

Inhibit the vestibular nuclei, used following chemotherapy or surgery. SE: headache, constipation, flushing.

Question 5

Substance P antagonists

Answer 5

Inhibit substance P which potentiates serotonin, thus result in lower serotonin signaling and lower stimulation of the vestibular nuclei. SE: constipation, diarrhea, abdominal pain, anorexia.

Question 6

Name 5 antiemetics

Answer 6

H1 antagonists, M1 antagonists, Dopamine 2 antagonists, Serotonin antagonists, Substance P antagonists.