Diuretics

Question 1

CA inhibitors

Answer 1

Inhibit CA stopping HCO3 production and inhibiting Na absorption, lead to the loss of pH regulation.

Question 2

Osmotic Diuretics

Answer 2

Mannitol can be excretes but not reabsorbed, osmotic activity increases diuresis.

Question 3

Loop Diuretics

Answer 3

Inhibit NKCC2 channel (Na, Cl, K). Most potent diuretic, used to treat hypertension and edema.

Question 4

Thiazide Diuretics

Answer 4

Inhibit NKC channel (Na, K, Cl, Ca), relaxes resistance vessels after a week or two.

Question 5

K+ Saving Diuretics

Answer 5

Amilioride inhibits ENaC channel
Spironolactone inhibits the aldosterone receptor.

Question 6

ADH antagonists

Answer 6

V2 stops the translocation if AQP2 in the collecting ducts. V1 inhibition causes vasodilation.

Question 7

Aldosterone analogues

Answer 7

A1 inhibition leads to disabling of TGF
A2 stimulation causes afferent arteriole vasodilation.

Question 8

Name 7 Diuretic Drugs

Answer 8

CA inhibitors, osmotic diuretics, loop diuretics, thiazide diuretics, K+ saving diuretics, ADH inhibitors, aldosterone analogues.