Hyperlipidemia Drugs

Question 1

Statins

Answer 1

Inhibit HMGCoA reductase and stop cholesterol synthesis, up regulate LDL receptor in the liver. Side effect is muscle atrophy and pain.

Question 2

Resins

Answer 2

Bind bile acids in the gut and thus stop their reabsorption, meaning that more needs to be made from cholesterol. Side effects are migraine, diarrhea, nausea.

Question 3

Fibrates

Answer 3

Activate PPARalpha and increase the transcription of enzymes needed for lipid metabolism. Side effects are muscle pain and atrophy, nausea and vomiting.

Question 4

Cholesterol absorption inhibitors

Answer 4

Inhibit cholesterol absorption in the small intestine. SE: diarrhea and flatulence.

Question 5

PCSK9 inhibitors

Answer 5

PCSK9 is an LDL inhibitor, when it is inhibited there is an increased uptake of LDLs.

Question 6

Name 5 drugs for hyperlipidemia

Answer 6

Statins, resins, fibrates, cholesterol absorption inhibitors and PCSK 9 inhibitors.