Heart Failure Drugs

Question 1

Beta blockers

Answer 1

Inhibit compensatory mechanisms which worsen heart failure.

Question 2

ACE inhibitors / ARBs

Answer 2

Decrease preload and after-load and increase cardiac output.

Question 3

ARNIs

Answer 3

ARBs and also inhibit reprolysin which breaks down useful natriuretic peptides. They decrease hypertrophy and blood pressure and increase cardiac output.

Question 4

Diuretics

Answer 4

Acutely do not affect cardiac output but can in the long run decrease afterload and increase cardiac output.

Question 5

Dogotalis

Answer 5

Competes with K for the sodium potassium atpase and inhibits na exchange for ca, thus increases contractility. Overdose leads to arrhythmia and blurred vision.

Question 6

Ivabradin

Answer 6

Blocks ion channel in the sinus node and decreases heart rate slightly raising cardiac output by raising filling time.

Question 7

SGLT2 inhibitors

Answer 7

Block kidney glucose transporter, glucose is excreted and pulls water. Has cardiovascular protection but may lead to more UTIs.

Question 8

Name 7 drugs to treat heart failure

Answer 8

Beta blockers. Calcium channel blockers. Ace inhibitors or arbs. Arnis. Diuretics. Digitalis. Ivabradin and SGLT2 inhibitors.