Anti Inflammatory Drugs

Question 1

NSAIDs

Answer 1

COX inhibitors, TxS (cox1) vs PGI2 (cox2). Celecoxib selective for cox 2.

Question 2

Glucocorticoids

Answer 2

Inhibit NFkB and AP1 and decrease prounflammatory cytokines and lymphocyte recruitment. Activate GRE which creates antiinflammatory factors like annexin 1 which stops prostaglandin synthesis. SE kushings syndrome (lipolysis, abdominal fat deposition, skin thinning, impaired wound healing, osteoporosis, diabetes, moos instability and sleep disturbances.

Question 3

Methatraxate

Answer 3

Folic acid antagonist which inhibits DNA and RNA synthesis and targets rapidly dividing cells.

Question 4

Ciclosporin

Answer 4

Binds cyclophilin and activates it, inhibits calmodulin and calcinurin and thus stops NFkB activation and the production of pro inflammatory cytokines like IL2

Question 5

Chloroquine

Answer 5

Inhibits proteosome and lysosome, inhibits APCs.

Question 6

Etaracept

Answer 6

TNF alpha receptor antibody blocks it.

Question 7

Anabenra

Answer 7

IL1 receptor agonist

Question 8

Abatacept

Answer 8

Targets costimulation molecules like CD 80/86.

Question 9

Other antibodies

Answer 9

IL2R, IL6R, CD20