Type 1 Diabetes

Question 1

What is type 1 diabetes associated with?

Answer 1

Insulin hyposecretion due to beta-cell loss, commonly from autoimmunity

Question 2

What genetic factor is associated with type 1 diabetes

Answer 2

: HLA variants that alter the MCH protein’s regulation of the adaptive immune response

Question 3

What can uncontrolled type 1 diabetes lead to

Answer 3

Respiratory alkalosis

Question 4

What causes insulin hyposecretion in type 1 diabetes

Answer 4

A deficiency in secretion due to loss of pancreatic beta-islet cells

Question 5

What is type 1a diabetes

Answer 5

The most common form of type 1 diabetes, where beta-cell loss is due to autoimmunity.

Question 6

What is type 1b diabetes

Answer 6

A rare form of type 1 diabetes where the cause of beta-cell loss is unknown

Question 7

What drives beta-cell death in type 1 diabetes

Answer 7

Autoimmunity, islet amyloid deposition, inflammatory cytokines, oxidative stress, and high glucose levels.

Question 8

What is included in type 1 diabetes management

Answer 8

Insulin injections, continuous glucose monitoring, and pancreatic transplantation for severe cases.

Question 9

What are the complications of type 1 diabetes

Answer 9

Kidney disease, retinopathy, peripheral neuropathy, stroke, infection, and liver disease.