Neuropsychiatric disorders Vitamin D Flashcards
What are the sources and roles of vitamin D in the body
What are the metabolic pathways and active forms of vitamin D
how does epidemiology identifies neuropsychiatric risk factors
how is vitamin D linked to schizophrenia
What is the function of Vitamin D
Known primarily for calcium and phosphorus homeostasis
How do you get Vitamin D
More than 90% of vitamin D is synthesised from exposure to UVB radiation
▪ However, dietary supplements are available
Where is the Vitamin D receptor expressed
▪ The Vitamin D receptor is expressed in the brain
▪ Particularly in dopaminergic regions and during dopamine development
What are the 3 main arguments for Developmental vitamin D and schizophrenia
Three main arguments:
* Children born in the city have a higher risk than those born in rural regions.
* Children of dark skinned migrants that migrate to colder climates have an increased risk.
* Seasonal birth rates.
What links low prenatal vitamin D and schizophrenia
Low prenatal vitamin D impacts adversely on brain development, leaving the affected offspring at increased risk of schizophrenia
