Glucagon Mechanisms Flashcards
1
Q
How does glucagon increase blood glucose levels
A
Glucagon stimulates liver hepatocytes to produce glucose via glycogenolysis and gluconeogenesis, and it stimulates adipocytes to produce fatty acids
2
Q
: Describe the mechanism of glucagon action
A
Glucagon binds to GPCRs, activates AC, increases cAMP, and activates the PKA pathway, which promotes glycogenolysis, gluconeogenesis, and blocks glycolysis
3
Q
What is GLP-1, and what does it do?
A
GLP-1 is a byproduct of preproglucagon that binds to GPCRs on beta cells to promote insulin release via the cAMP/PKA pathway while inhibiting glucagon release
4
Q
Why is GLP-1 used in type 2 diabetes treatment
A
GLP-1 promotes insulin release, making it a key therapeutic target for managing blood glucose in type 2 diabetes
