Glucagon Mechanisms Flashcards
(4 cards)
How does glucagon increase blood glucose levels
Glucagon stimulates liver hepatocytes to produce glucose via glycogenolysis and gluconeogenesis, and it stimulates adipocytes to produce fatty acids
: Describe the mechanism of glucagon action
Glucagon binds to GPCRs, activates AC, increases cAMP, and activates the PKA pathway, which promotes glycogenolysis, gluconeogenesis, and blocks glycolysis
What is GLP-1, and what does it do?
GLP-1 is a byproduct of preproglucagon that binds to GPCRs on beta cells to promote insulin release via the cAMP/PKA pathway while inhibiting glucagon release
Why is GLP-1 used in type 2 diabetes treatment
GLP-1 promotes insulin release, making it a key therapeutic target for managing blood glucose in type 2 diabetes