TXA/ Transexamic Acid

Question 1

TXA Class

Answer 1

Antifibrinolytic Agent

Question 2

TXA Action

Answer 2

Binds to plasminogen’s lysine receptor site and blocks the conversion of plasminogen to plasmin. The amount of plasmin is reduced thereby reducing the amount of fibrin(clot) breakdown

Question 3

TXA Indications

Answer 3

• > 14 y/o or over 100 lbs(45.5 kgs).
• < 3 hrs post injury; ideal is < 1 hr post injury.
• SBP < 90
• Risk of significant bleeding, blood transfusion, or surgery.
• Multisystem trauma, patients with clinical concerns for bleeding in non-compressible areas.

Question 4

TXA Contraindications

Answer 4

• > 3 hrs post injury.
• Age < 14 y/o or < 100 lbs (45.5 kgs).
• Isolated head injury.
• Isolated spinal shock.
• Non-blood loss injury.
• Isolated extremity hemorrhage where bleeding can be controlled and possibility of re-implantation exists.

Question 5

TXA Dosage

Answer 5

Adult/Peds(>14 or 100 lbs) dose the same:

• IV/IO- 1 gram in 100mL NS over 10min.

Question 6

TXA Onset/Duration

Answer 6

• Onset: unknown

* Duration: 3 hrs

Question 7

TXA Side Effects

Answer 7

• Fatigue
• HA
• N/V/D
• Vision changes
• Dizziness

Question 8

TXA Pregnancy Class

Answer 8

Class (B)