Ranitidine/ Zantac Flashcards
1
Q
Ranitidine Class
A
- Antihistamine
* H2 Antagonist
2
Q
Ranitidine Action
A
• Blocks H2 receptors
- H1—causes bronchoconstriction, contraction of gut
- H2—causes peripheral vasodilation, secretion of gastric acid.
3
Q
Ranitidine Indications
A
- Anaphylaxis
- Allergic reactions
- Urticaria
4
Q
Ranitidine Contraindications
A
- Hypersensitivity
- Acute asthma attack
- Lower respiratory tract disease/Pneumonia
- Newborns & nursing mothers
5
Q
Ranitidine Precautions
A
- Concurrent use of other H2 inhibitors
- HTN
- Cardiac disease
- Renal disease (prolonged clearance)
- Bronchial asthma
- Seizures
- Pregnancy category - C
- Closed angle glaucoma (avoid if at all possible)
6
Q
Ranitidine Dosage
A
Adults:
• IV/IO/IM 50 mg (Diluted in Normal Saline)
• PO: (If available) 150-300 mg (for mild cases)
Pediatrics:
• 1 mg/kg IV/IM/IO max dose 50 mg
• PO: (If available) 150 mg (for mild cases)
7
Q
Ranitidine Onset/ Duration
A
Onset: IM—20 min. IV—5-10 min to reach peak effect.
Duration: IM—2-6 hours. IV—2-6 hours
8
Q
Ranitidine Side Effects
A
- Drowsiness
- Dizziness
- Incoordination
- Confusion
- Dry mouth
- Drying of bronchial secretions
- Blurred vision
- Urinary retention
- Hypotension
- Tachycardia
- Bradycardia
- AV Block (rare)
9
Q
Ranitidine Interactions
A
- Additive effects—other CNS depressants.
* MAOIs—prolong the anticholinergic effects.
