Labetalol

Question 1

Labetalol Class

Answer 1

Alpha/ Beta adrenergic blocker

Question 2

Labetalol Action

Answer 2

• Selective Alpha 1-adrenergic blockade
• Non-selective beta-adrenergic blockade
• Reduction of BP w/o reflex tachycardia or bradycardia

Question 3

Labetalol Indications

Answer 3

• BP management in ischemic strokes that received tPA. Goal SBP<180 and/or DBP<105
• BP management in patients with confirmed intracranial hemorrhage. Goal SBP<160 and/or DBP<90

Question 4

Labetalol Contraindications

Answer 4

• Bronchial asthma (relative)
• Overt Cardiac Failure
• High degree heart blocks(>than 1st degree)
• Cardiogenic shock
• Severe Bradycardia

Question 5

Labetalol Dosage

Answer 5

• IV/IO: 10-20mg MAX single dose 20mg. Repeat in 10 min PRN. MAX total dose 50mg.
• Continuous infusion: 2-8mg/min. Increase by 2mg/min q 10 min. MAX 8mg/min

Question 6

Labetalol Onset/Duration

Answer 6

• Onset: 2-3 min, peak effect @ 15min.

* Duration: 2 hrs

Question 7

Labetalol Side Effects

Answer 7

• CNS- dizziness, tingling scalp/skin, numbness, vertigo.
• Respiratory- wheezing and bronchospasm.
• Cardiac- hypotension, Ventricular dysrhythmias, syncope, bradycardia, and heart block.
• Other- N/V.

Question 8

Labetalol Interactions

Answer 8

Additive cardiac depression and toxicity when used concomitantly with lidocaine or CCB.