Narcan/ Naloxone

Question 1

Narcan Class

Answer 1

Narcotic Antagonist

Question 2

Narcan Action

Answer 2

Binds competitively to opiate receptor sites, displacing narcotics and synthetic narcotics. Antagonizes all actions of narcotics

Question 3

Narcan Indication

Answer 3

• Complete or partial reversal of depression caused by narcotics or synthetic narcotics
• Coma of unknown etiology

Question 4

Narcan Contraindication

Answer 4

• Known Hypersensitivity

Question 5

Narcan Precaution

Answer 5

• Pre-existing cardiac disease
• Patients who have received cardiotoxic drugs
• Abrupt and complete reversal can cause withdrawal-type effects
• Pregnancy (B)
• Use with caution in polypharmaceutical overdoses

Question 6

Narcan Dosage

Answer 6

Adults:
• IV/IO: 0.1-2 mg slowly. Repeat as needed q 1-2 min to a max of 10 mg.
• IM/IN: 2-4 mg. Repeat PRN to a max of 10 mg. If IV access is unavailable.
• If patient has obviously aspirated, consider bypassing Narcan and manage airway as required.
• IV/IO in cardiac arrest: 2 mg.
Pediatrics:
• IV/IO: 0.01 - 0.05 mg/kg to max single dose of 2 mg. Admin slowly. Repeat PRN q 1-2 min to a max of 10 mg.
• IM/IN: 2-4 mg. Repeat PRN to a max of 10 mg. If IV/IO
access is unavailable.
• If patient has obviously aspirated, consider bypassing Narcan and manage airway as required.
• IV/IO in cardiac arrest: 2 mg

Question 7

Narcan Onset/ Duration

Answer 7

• Onset: IV/IO–1-2 min. IN: 1-4 min. IM/ SubQ: 2-8 min.

* Duration: IV/IM/IN/ET/SubQ–30-60 minutes

Question 8

Narcan Side Effects

Answer 8

• Tachycardia
• Hypotension
• HTN
• Dysrhythmias
• N/V
• Diaphoresis

Question 9

Narcan Interactions

Answer 9

Incompatible with alkaline drugs