Tumor Supressors & Oncogenes

Question 1

abl

Answer 1

oncogene (CML. Gene product = tyrosine kinase receptor)

Question 2

APC

Answer 2

suppressor (FAP associated with familial colorectal cancer)

Question 3

bcl-2

Answer 3

Oncogene (causes Follicular lymphoma t;(14:18) and undifferentiated lymphomas.) (activated by c-myc and inhibits apoptosis by stabilizing mitchondrial membrane)

Question 4

BRAF

Answer 4

suppressor (causes melanoma and Papillary Thyroid cancer. Encodes RAF protein, which is downstream of RAS and controls gene expression)

Question 5

BRCA 1 and 2

Answer 5

supressors (products are DNA repair proteins)

Question 6

c-kit

Answer 6

oncogene (GIST [gastrointestinal stromal tumors]. Gene product = tyrosine kinase receptor)

Question 7

c-myc

Answer 7

Oncogene (causes Burkitt’s Lymphoma)

Question 8

DCC

Answer 8

suppressor (colon cancer)

Question 9

DPC4

Answer 9

suppressor (pancreatic cancer)

Question 10

HER2/neu (c-ERB2)

Answer 10

Oncogene (breast, ovarian, and gastric carcinomas. Gene product = a tyrosine kinase receptor)

Question 11

L-myc

Answer 11

Oncogene (causes lung cancer. Gene product = a transcription factor)

Question 12

NF-1

Answer 12

suppressor (encodes GAP protein, which normally constitutively inhibits RAS and therefore gene expression)

Question 13

NF-2

Answer 13

suppressor (gene product = Merlin (schwannomin) protein)

Question 14

N-myc

Answer 14

Oncogene (causes neuroblastoma. Gene product = a transcription factor)

Question 15

p16

Answer 15

suppressor (causes melanoma)

Question 16

p53

Answer 16

suppressor (causes Li Fraumeni Syndrome. Gene product = transcription factor, important for intrinsic pathway of apoptosis)

Question 17

PDGF-beta

Answer 17

oncogene (causes astrocytoma. It’s a growth factor, and therefore a ligand for tyrosine kinase receptors).

Question 18

ras

Answer 18

oncogene (colon cancer)

Question 19

Rb

Answer 19

suppressor (retinoblastoma, osteosarcoma. Supposed to inhibit E2F, blocking G1–>S phase.)

Question 20

ret

Answer 20

Oncogene (MEN2A and MEN2B syndromes)

Question 21

WT1

Answer 21

suppressor (causes Wilm’s tumor / nephroblastoma)