Tumor Supressors & Oncogenes Flashcards
abl
oncogene (CML. Gene product = tyrosine kinase receptor)
APC
suppressor (FAP associated with familial colorectal cancer)
bcl-2
Oncogene (causes Follicular lymphoma t;(14:18) and undifferentiated lymphomas.) (activated by c-myc and inhibits apoptosis by stabilizing mitchondrial membrane)
BRAF
suppressor (causes melanoma and Papillary Thyroid cancer. Encodes RAF protein, which is downstream of RAS and controls gene expression)
BRCA 1 and 2
supressors (products are DNA repair proteins)
c-kit
oncogene (GIST [gastrointestinal stromal tumors]. Gene product = tyrosine kinase receptor)
c-myc
Oncogene (causes Burkitt’s Lymphoma)
DCC
suppressor (colon cancer)
DPC4
suppressor (pancreatic cancer)
HER2/neu (c-ERB2)
Oncogene (breast, ovarian, and gastric carcinomas. Gene product = a tyrosine kinase receptor)
L-myc
Oncogene (causes lung cancer. Gene product = a transcription factor)
NF-1
suppressor (encodes GAP protein, which normally constitutively inhibits RAS and therefore gene expression)
NF-2
suppressor (gene product = Merlin (schwannomin) protein)
N-myc
Oncogene (causes neuroblastoma. Gene product = a transcription factor)
p16
suppressor (causes melanoma)
p53
suppressor (causes Li Fraumeni Syndrome. Gene product = transcription factor, important for intrinsic pathway of apoptosis)
PDGF-beta
oncogene (causes astrocytoma. It’s a growth factor, and therefore a ligand for tyrosine kinase receptors).
ras
oncogene (colon cancer)
Rb
suppressor (retinoblastoma, osteosarcoma. Supposed to inhibit E2F, blocking G1–>S phase.)
ret
Oncogene (MEN2A and MEN2B syndromes)
WT1
suppressor (causes Wilm’s tumor / nephroblastoma)
