Hepatitis Flashcards
Best markers for current acute HBV infection
IgM anti-HBc & HBsAg
Best markers for past HBV infection
IgG anti-HBs & IgG anti-HBc In the absence of HBsAg
What markers will be present in an HBV vaccinated individual
IgG anti-HBs but no anti-HBc
Best marker for chronic HBV infection
HBsAg longer than 6 months but no anti-HBs
Best markers for HBV infectivity
HBV DNA or HBeAg
Diagnose: HBsAg: + Anti-HBs: - HBeAg: + Anti-HBe: - Anti-HBc: IgM
Acute HBV
Diagnose: HBsAg: - Anti-HBs: - HBeAg: - Anti-HBe: + Anti-HBc: IgM
HBV Window Period
Diagnose: HBsAg: + Anti-HBs: - HBeAg: + Anti-HBe: - Anti-HBc: IgG
High infectivity Chronic HBV
Diagnose: HBsAg: + Anti-HBs: - HBeAg: - Anti-HBe: + Anti-HBc: IgG
Low infectivity Chronic HBV
Diagnose: HBsAg: - Anti-HBs: + HBeAg: - Anti-HBe: + Anti-HBc: IgG
Recovery from HBV infection
Diagnose: HBsAg: - Anti-HBs: + HBeAg: - Anti-HBe: - Anti-HBc: -
Immunized against HBV
This Hepatitis virus is a Picornavirus
HAV
This Hepatitis virus is a Hepadnavirus
HBV
This Hepatitis virus is a Flavivirus
HCV
This Hepatitis virus is a Delta Virus
HDV
This Hepatitis virus is a Hepevirus
HEV
Which Hepatitis virus requires infection with which other hepatitis virus
HDV requires HBV infection
Which Hepatitis viruses carry a risk of Hepatocellular Carcinoma
HBV, HCV, & HDV
Which Hepatitis viruses are transmitted by blood or sexual contact
HBV, HCV, & HDV
Which Hepatitis viruses are transmitted by fecal oral route
HAV & HEV
Which Hepatitis viruses are naked viruses
HAV & HEV
When does a Hepatitis superinfection occur
When an HBV infected individual is infected with HDV
What is the standard treatment option for HBV & HCV
Alpha-interferon + Ribovirin
What percent of symptomatic HBV infected individuals develop acute vs chronic disease
Acute: 90% Chronic: 10%
What percent of symptomatic HCV infected individuals develop acute vs chronic disease
Acute: 20% Chronic: 80%
Which Hepatitis Virus causes high mortality in pregnant women
HEV
How do liver enzymes ALT and AST compare in viral hepatitis
ALT > AST
How do liver enzymes ALT and AST compare in alcoholic hepatitis
AST > ALT
IgM Anti-HAV Indicates what
Active HAV infection
IgG Anti-HAV indicates what
Prior HAV infection and/or HAV vaccination