DIT Rapid-Fire Facts Flashcards
Most common cause of neural tube defects
Folate deficiency
Most common cause of congenital malformations
Alcohol use during pregnancy
Most common cause of congenital mental retardation in the US
Fetal Alcohol Syndrome
Hyperflexible joints, arachnodactyly, aortic dissection, and lens dislocation
Marfan Syndrome
Hereditary Nephritis, Cataracts, and sensorineural hearing loss
Alport Syndrome
Unilateral facial drooping involving the forehead
Bells Palsy
Ptosis, miosis, and anhidrosis
Horner Syndrome
Amyloid deposits in gray matter of the brain
Senile plaques (Alzheimer Disease)
Drooling farmer
Organophosphate poisoning
Inability to breastfeed, amenorrhea, cold intolerance
Sheehan’s Syndrome
Infertility, galactorrhea, and bitemporal hemianopsia
Prolactinoma
4 most common causes of Cushing Syndrome
- Exogenous cortisol
- Ectopic ACTH
- Cushing Disease (Pituitary adenoma)
- Adrenal adenoma (very rare)
Most common tumor of the adrenal
Benign nonfunctional adrenal adenoma
Most common tumor of the adrenal medulla in adults
Pheochromocytoma
Most common tumor of the adrenal medulla in children
Neuroblastoma
Most common cause of primary hyperaldosteronism
Adrenal adenoma
Medical treatment for hyperaldosteronism
Spironolactone or Eplerenone
Medical treatment for pheochromocytoma
Non-selective alpha-blocker (phenoxybenzamine, phentolamine)
Pheochromocytoma, medullary thyroid cancer, and hyperparathyroidism
MEN2a
Pheochromocytoma, Medullary thyroid cancer, and mucosal neuromas
MEN2b
Adrenal disease associated with skin hyperpigmentation
Addison’s disease
HTN, hypokalemia, metabolic alkalosis
Conn syndrome (hyperaldosteronism)
Most common thyroid cancer
Papillary carcinoma of the thyroid
Cold intolerance
Hypothyroidism
Enlarged thyroid cells with ground-glass nuclei
These are called “Orphan Annie Eye” nuclei. Seen in Papillary carcinoma of thyroid
Most common infections seen in chronic granulomatous disease
Staph Aureus, E. Coli, Klebsiella, Aspergillus, Candida
Eczema, recurrent URI, high serum IgE
Hyperimmunoglobulin E syndrome (JOB syndrome)
Large lysosomal vesicles in phagocytes
Chediak-Higashi disease
Dark purple nodules on the skin in an HIV patient
Kaposi Sarcoma
Large cells with owl’s eye inclusions
CMV
Treatment for CMV
Ganciclovir
Most common opportunistic infection in HIV patients
Pneumocystis jiroveci
Drug used to prevent pneumocystis jiroveci Pneumonia
TMP-SMX
Dysphagia, glossitis and iron deficiency anemia
Plummer-Vinson Syndrome
Hematemesis with retching
Usually Mallory Weiss Tear
Mucin-filled cell with a peripheral nucleus
Signet-ring cell seen in gastric cancer
Most common type of stomach cancer
Adenocarcinoma
Ovarian metastasis from gastric cancer
Krukenberg tumor
Gastric ulcerations and high gastrin levels
Zollinger-Ellison Syndrome
Acute gastric ulcer associated with elevated ICP or head trauma
Cushing ulcer
Acute gastric ulcer associated with severe burns
Curling ulcer
Painless jaundice
Pancreatic cancer (especially in the head of the pancreas)
Most common cause of acute pancreatitis
Gallstones & Alcohol
Most common cause of chronic pancreatitis
Alcohol abuse
Standard treatment for DKA
IV fluids, IV insulin, Potassium replacement
Standard treatment for Type I DM
Insulin + low glycemic diet
Standard treatment for Type II DM
Oral hypoglycemic drugs, possibly insulin, low-sugar diet, weight loss
Weight loss, diarrhea, arthritis, fever, adenopathy, and hyperpigmentation
Whipple disease
Anti-transglutaminase/anti-gliadin/anti-endomysial antibodies
Celiac disease
Vitamin given to pregnant women to prevent neural tube defects
Folate
Triglyceride accumulation in hepatocytes
Fatty Liver Disease
Eosinophilic inclusions in the cytoplasm of hepatocytes
Mallory bodies
Cancer closely linked to cirrhosis
Hepatocellular Carcinoma
Sever hyperbilirubinemia in a neonate
Type I Crigler-Najjar Syndrome
Mild, benign hyperbilirubinemia
Gilbert Syndrome
Hepatomegaly, abdominal pain, ascites
Budd-Chiari Syndrome (No JVD)
Green/yellow corneal deposits
Wilson Disease
Low serum ceruloplasmin
Wilson Disease
Cirrhosis, diabetes and hyperpigmentation
Hemochromatosis
Treatment for chronic hepatitis
Interferon Alpha
Preferred anticoagulant for immediate anticoagulation
Heparin or Low Molecular Weight Heparin
Preferred anticoagulant for long-term anticoagulation
Warfarin
Preferred anticoagulant during pregnancy
Heparin or Low Molecular Weight Heparin
A boy with self-mutilating behavior, mental retardation, and gout
Lesch-Nyhan Syndrome
Elevated Uric Acid levels
Gout
Lesch-Nyhan syndrome
Tumor Lysis syndrome
Loop or thiazide diuretics
Bluish-colored lines on the gingivae
These are Burton’s lines, seen in lead poisoning
Causes of hypochromic, microcytic anemia
Iron deficiency
Thalassemia
Lead poisoning
Hypersegmented neutrophils
Megaloblastic anemia (Usually B12 or Folate deficiency)
Skull x-ray shows a “hair-on-end” appearance
Marrow hyperplasia (Beta Thalassemia or sickle cell anemia)
Basophilic stippling of RBCs
Lead poisoning
Painful cyanosis of the finger and toes, with hemolytic anemia
Cold agglutinins (cold autoimmune hemolytic anemia)
Red urine in the morning, and fragile RBCs
Paroxysmal nocturnal hemoglobinuria
Basophilic nuclear remnants in RBCs
Howell-Jolly bodies
Autosplenectomy
Sickle Cell disease
Drug used to treat sickle cell disease
Hydroxyurea
Antiplatelet Antibodies
Immune Thrombocytopenic Purpura
Bleeding disorder with gpIb deficiency
Bernard-Soulier Disease
Most common inherited bleeding disorder
VwF disease
Cancer most commonly associated with a noninfectious fever
Hodgkin Lymphoma
“Smudge cells”
CLL
“Punched out” Lytic lesions
Multiple Myeloma
Sheets of lymphoid cells, with a “Starry sky” appearance
Burkitt Lymphoma
RBCs clumped together like a stack of coins
Multiple Myeloma
Monoclonal antibody spike
Multiple Myeloma
MGUS
Waldenstrom Macroglobulinemia
Reddish-Pink rods in the cytoplasma of leukemic blasts
Auer Rods
Large B cells with bilobed nuclei and prominent “Owl’s eye inclusions”
Reed Sternberg Cells
Treatment of choice for rickets or osteomalacia
Vitamin D supplementation
Swollen gums, poor wound healing, bleeding mucous membranes, and spots on the skin
Vitamin C deficiency (Scurvy)
Most common vitamin deficiency in the US
Folate deficiency
Hypersegmented neutrophils
Megaloblastic anemia (B12 or folate deficiency)
Dilated cardiomyopathy, edema, and polyneuropathy
Thiamine (Vitamin B1) deficiency
Wet Beriberi sx include the cardiomyopathy and edema
Dry Beriberi sx include the polyneuropathy
Most common cancer of the appendix
Carcinoid tumor
Most common surgical emergency
Appendicitis
GI hamartomas, hyperpigmentation of the mouth and hands
Peutz-Jeghers syndrome
Multiple colon polyps, osteomas, soft tissue tumors
Gardner syndrome
Severe right lower quadrant pain with rebound tenderness
Appendicitis (this is McBurney’s sign)
“Apple core” lesion on barium enema
Colon cancer
Most common site of colonic diverticula
Sigmoid colon
“string sign” on contrast x-ray
Crohn’s disease
“lead pipe” appearance of colon on contrast x-ray
Ulcerative colitis
Food poisoning due to exotoxin
Staph Aureus or Bacillus Cereus
Osteomyelitis in sickle cell disease
Salmonella
Ring-enhancing brain lesion in an HIV patient
Toxoplasma Gondii
Treatment for Trichomonas Vaginalis
Metronidazole
Most common protozoal diarrhea
Giardia lamblia
Most common helminth infection in the US
Enterobius Vermicularis
Second most common helminth infection in the US
Ascaris Lumbricoides
Chronic sinusitis, infertility, and situs inversus
Kartagener Syndrome