Tumor Immunology

Question 1

2 key cytokines that down-regulate T cell responses

Answer 1

TGF-beta and IL-10

Question 2

Ligand that provides activatory signals to NK cells

Answer 2

MIC

Question 3

MIC ligand provides activatory signals to NK cells through this

Answer 3

NKG2D

Question 4

MIC ligand activates these cells

Answer 4

NK cells

Question 5

Pembrolizumab, Nivolumab, and Cemiplimab are monoclonal antibodies against this

Answer 5

PD-1

Question 6

Atezolizumab, Avelumab, and Durvalumab are monoclonal antibodies against this

Answer 6

PD-L1

Question 7

PD-L1/PD-1 binding has this effect

Answer 7

Inhibits T cell killing of tumor cell

Question 8

Blocking PD-L1/PD-1 binding has this effect

Answer 8

Allows T cell killing of tumor cell

Question 9

Antigen for Gemtuzumab

Answer 9

CD33

Question 10

CD33 is a marker for these

Answer 10

Immature myeloid cells

Question 11

Gemtuzumab is used for this disease

Answer 11

Acute myelogenous leukemia

Question 12

Ibritumomab is used for this disease

Answer 12

Non-Hodgkin’s lymphoma

Question 13

Tositumomab is used for this disease

Answer 13

Non-Hodgkin’s Lymphoma

Question 14

Monoclonal antibody against CD33 for treatment of acute myelogenous leukemia

Answer 14

Gemtuzumab

Question 15

2 monoclonal antibodies that target CD20 in the treatment of Non-Hodgkin’s Lymphoma

Answer 15

Ibritumomab and Tositumomab

Question 16

Antigen target of Ibritumomab

Answer 16

CD20

Question 17

Antigen target of Tositumomab

Answer 17

CD20

Question 18

Monoclonal antibody linked directly to the cytotoxic antibiotic dervided ozogamicin

Answer 18

Gemtuzumab

Question 19

Gemtuzumab is linked directly to this

Answer 19

Cytotoxic antibiotic derived Ozogamicin

Question 20

Monoclonal antibody linked through the chelator tiuxetan to indium-111 for imaging and yttrium-90 for treatment

Answer 20

Ibritumomab

Question 21

Ibritumomab is linked through this to indium-111 for imaging and yttrium-90 for treatment

Answer 21

The chelator Tiuxetan

Question 22

Ibritumomab is linked through the chelator tiuextan to this for imaging

Answer 22

Indium-111

Question 23

Ibritumomab is linked through the chelator tiuextan to this for treatment

Answer 23

Yttrium-90

Question 24

Monoclonal antibody that is linked to iodine-131

Answer 24

Tositumomab

Question 25

Tositumomab is linked to this

Answer 25

Iodine-131

Question 26

Vaccination using these proteins from dying tumor cells has demonstrated a potential for strong anti-tumor responses

Answer 26

Heat shock

Question 27

T cell that recognizes antigen like a B cell (recognize protein)

Answer 27

Chimeric antigen receptor (CAR) T cells

Question 28

How are CAR T cells different from regular TCRs?

Answer 28

Recognize proteins (antibody-like); recognize antigen directly
Normal TCRs recognize peptide:MHC

Question 29

Fusion protein of antigen-binding region from heavy and light chains connected by a 10-25 amino acid linker

Answer 29

Single-chain variable fragment (scFv)