Transplant Flashcards
Antigens responsible for hyperacute rejection
ABO antgiens
Antigens responsible for acute and chronic rejection
HLA antigens
ABO antigens cause this type of rejection
Hyperacute
HLA antigens cause these types of transplant rejection
Acute and chronic
Hyperacute rejection is due to this type of immune response
Humoral response
due to preformed antibodies against ABO antigens
Type of transplant rejection with immediate cyanosis and mottled appearance
All vessels have fibrinoid necrosis and thrombotic occlusion
Neutrophils in vessels and vessel walls
Hyperacute rejection
Acute rejection is due to this type of immune response
Type IV hypersensitivity reaction against MHC antigens
Caused by CD8 or CD4 T cells
Target for T cells in acute rejection
Graft parenchymal cells
(renal tubulitis, renal vascular endothelialitis)
Is acute rejection responsive to immunosuppression?
Yes
Chronic rejection is due to this type of immune response
T cell reaction with fibrogenic cytokines
Is chronic rejection responsive to immunosuppression?
No
Cellular infiltrate is less conspicuous in this type of rejection
Chronic
Mononuclear infiltrates are seen in this type of rejection
Acute rejection
When does acute rejection begin?
Days to weeks after transplant (or with decreased immunosuppression)
When does chronic rejection begin?
Occurs years after transplantation