Transplant Flashcards

1
Q

Antigens responsible for hyperacute rejection

A

ABO antgiens

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2
Q

Antigens responsible for acute and chronic rejection

A

HLA antigens

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3
Q

ABO antigens cause this type of rejection

A

Hyperacute

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4
Q

HLA antigens cause these types of transplant rejection

A

Acute and chronic

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5
Q

Hyperacute rejection is due to this type of immune response

A

Humoral response
due to preformed antibodies against ABO antigens

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6
Q

Type of transplant rejection with immediate cyanosis and mottled appearance
All vessels have fibrinoid necrosis and thrombotic occlusion
Neutrophils in vessels and vessel walls

A

Hyperacute rejection

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7
Q

Acute rejection is due to this type of immune response

A

Type IV hypersensitivity reaction against MHC antigens
Caused by CD8 or CD4 T cells

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8
Q

Target for T cells in acute rejection

A

Graft parenchymal cells
(renal tubulitis, renal vascular endothelialitis)

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9
Q

Is acute rejection responsive to immunosuppression?

A

Yes

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10
Q

Chronic rejection is due to this type of immune response

A

T cell reaction with fibrogenic cytokines

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11
Q

Is chronic rejection responsive to immunosuppression?

A

No

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12
Q

Cellular infiltrate is less conspicuous in this type of rejection

A

Chronic

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13
Q

Mononuclear infiltrates are seen in this type of rejection

A

Acute rejection

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14
Q

When does acute rejection begin?

A

Days to weeks after transplant (or with decreased immunosuppression)

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15
Q

When does chronic rejection begin?

A

Occurs years after transplantation

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16
Q

Type of rejection that involves T cell reaction with fibrogenic cytokines
Produces interstitial fibrosis and vascular narrowing of all vessels

A

Chronic rejection

17
Q

Graft vs Host disease involves these type of cells attacking recipient tissues

A

Donor T cells