HIV Flashcards
This HIV protein binds cell surface proteins CD4 and CCR5
p120
What is protein p120?
Protein on HIV that binds cell surface proteins CD4 and CCR5
Both proteins needed for infection to occur
People with this homozygous mutation are resistant to HIV infection
CCR5
Both CD4 and CCR5 are needed for infection to occur
What is the result of HIV infection of a quiescent T cell?
Latent infection
Viral RNA remains linear and cytoplasmic
What is the result of HIV infection of an activated proliferating T cell?
Cell death
Viral RNA integrates into host genome
Type of T cell that Proliferating infected cell sheds virus and is killed
Th cells
2 cells that are not killed by HIV infection, but serve as reservoirs of infection (important when Th count is very low)
Macrophage and Dendritic cell
Probable initial infected cell at mucosal inoculation
Dendritic cell
Cell that Brings infection to other tissue sites (microglia, etc)
Macrophage
Cell that Brings HIV infection to lymph nodes and more CD4+ T cells
Dendritic cell
This begins 3-6 weeks after HIV infection and lasts 2-4 weeks
Acute retroviral syndrome
How do you get loss of barrier function at mucosal sites and microbial invasion often with diarrhea in acute retroviral syndrome?
Infection and death of memory T cells at mucosal site
How do you get generalized lymphadenopathy and viremia in acute retroviral syndrome?
Dendritic cells bring HIV to lymph nodes
Acute retroviral syndrome is characterized by generalized ______ and _______
Lymphadenopathy and Viremia
When does seroconversion (making Abs; humoral response) occur in acute retroviral syndrome?
3-7 weeks
Fever, sore throat, fatigue, rash, and lymphadenopathy are symptoms of this
Acute retroviral syndrome
What affect does the cell-mediated response have on viremia?
Decreased
When does the cell-mediated response (and subsequent decreased viremia) occur in acute retroviral syndrome?
12 weeks
Does the humoral response or cell-mediated response occur 3-7 weeks in acute retroviral syndrome?
Humoral (seroconversion)
Does the humoral response or cell-mediated response occur 12 weeks in Acute retroviral syndrome?
Cell mediated (decrease viremia)
Seroconversion takes 3-7 weeks after infection, and these are detectable a little earlier
Viral particles or p24 capsid protein
Long period of stable viremia and gradual decreased CD4+ T cells
Latency period
CD4 count trend in latency period
Gradually decreases
Viral load count trend in latency period
Gradually increases
Period where HIV is replicating in spleens, lymph nodes
Latency period
Symptoms of HIV during the latency period
Usually asymptomatic
May have minor opportunistic infections (Candida, Tb, Herpes)
Occasionally have autoimmune thrombocytopenia
Level of viremia reaches plateau with onset of this
Cell mediated response
This level predicts the time course to AIDS
Level of viremia that reaches plateau with CMI onset
This count is assessment of current immune deficiency
CD4 count
Viremia level of >36k predicts 62% chance of this at 5 years
AIDS
Viremia level of <4k predicts 5% chance of this at 5 years
AIDS
Viremia level of this predicts 62% chance of AIDS at 5 years
> 36k