Tuberculosis Flashcards
1
Q
Which type of hypersensitivity reaction is involved?
A
Delayed type IV
2
Q
What is its defining pathological feature?
A
Granulomas with caseous necrosis
3
Q
Main pathogens
A
M. Tuberculosis and M. Bovis
4
Q
What does the T cell response to infection cause?
A
Inflammation
Tissue necrosis
Scarring
5
Q
Primary TB
A
Infection occurs within a few weeks of exposure - clinical features present
6
Q
Secondary TB
A
Reinfection or reactivation of disease in a person with some immunity
7
Q
Where does Primary TB mainly effect?
A
Periphery of mid zone of lungs and large hilar nodes
8
Q
Where does secondary TB mainly effect?
A
Apices (cavitation)
9
Q
Why does latent TB reactivate?
A
Age
Other disease - think HIV
Immunosupressive therapy
10
Q
What test should be done if someone has TB?
A
HIV
