Lung Cancer

Question 1

Hormone production of squamous cell

Answer 1

PTH

Question 2

Hormone production of small cell

Answer 2

ATCH

Question 3

Which group does small cell mainly affect?

Answer 3

Smokers

Question 4

What is the most common type of lung cancer in non-smokers?

Answer 4

Adenocarcinoma

Question 5

4 Types of lung cancer

Answer 5

Adenocarcinoma
Squamous cell
Small cell
Large cell

Question 6

Which type has the worst prognosis?

Answer 6

Small cell

Question 7

What do adenomas express?

Answer 7

TTF

Question 8

What does small cell express?

Answer 8

p63 and high molecular weight cytokeratins

Question 9

Oncogenes of small cell

Answer 9

myc

Question 10

Oncogenes of non-small cell

Answer 10

myc, K-ras, her2

Question 11

Tumour supressor genes of small cell

Answer 11

p53, Rb, 3p

Question 12

Tumour supressor genes of non-small cell

Answer 12

p53, 1q, 3p, 9p, 11p, Rb

Question 13

Which tumours respond to tyrosine kinase inhibitors?

Answer 13

Adenocarcinomas - mainly in non-smoking asians

Question 14

Bronchial tumours

Answer 14

Squamous metaplasia
Dysplasia
Carcinoma in situ
Invasive malignancy

Question 15

What is the median survival for all lung cancer patients?

Answer 15

5.8 months

Question 16

What does small cell respond well to?

Answer 16

Chemotherapy

Question 17

What are the main treatment options for non-small cell?

Answer 17

Surgery or radical radiotherapy

Question 18

Which type of lung cancer has the worst prognosis?

Answer 18

Small cell

Question 19

Median survival rate with surgery?

Answer 19

42.7 months

Question 20

Which tests are often used to stage the cancer for surgery?

Answer 20

Bronchoscopy
Endobronchial US
CT of brain and thorax
PET scan

Question 21

Which tests are used to stage cancer for chemotherapy?

Answer 21

Bronchoscopy/tissue sampling
CT scan
Performance status ECOG score