Pharmacology Flashcards
1
Q
Bronchial smooth muscle contraction
A
M3 muscarinic ACh receptors
2
Q
Bronchial smooth muscle relaxation
A
B2 adrenoceptors activated by adrenaline
3
Q
Phosphorylation of MLC
A
Contraction
4
Q
Dephosphorylation of MLC
A
Relaxation
5
Q
Change in bronchioles in asthma
A
- Increased mass of smooth muscle
- More interstitial fluid
- More mucus
- Epithelial damage
- Sub-Epithelial fibrosis
6
Q
Bronchospasm and acute inflammation
A
Type I hypersensitivity reaction
7
Q
Delayed inflammation
A
Type IV hypersensitivity reaction
8
Q
Nonatopic
A
Low-level TH1 response involving IgG
9
Q
Atopic
A
Strong TH2 response involving IgE
10
Q
Eosinophil interleukin
A
IL-5 from TH2 cells
11
Q
Mast cell interleukin
A
IL-4 and IL-13 from TH2 cells
12
Q
Cells involved in the effector phase of asthma
A
Eosinophils and mast cells
13
Q
Receptors on mast cells in airway tissue
A
IgE
14
Q
Effects of cross linked IgE on mast cells
A
- Stimulates Ca+ entry into mast cell
2. Release of Ca+ from stores
15
Q
Activated mast cell
A
- Releases secretory granules - cause smooth muscle contraction
- Release facts which attract cells to cause inflammation
