Tu - Examples of Gram-negative infections

Question 1

What does MRSA stand for? (per letters)

Answer 1

Metcillin resistant staphylococcus aureus

Question 2

Why is MRSA resistant to penicillin? (explain complicated)

Answer 2

Because MRSA has the MeCa gene, which means it produces PBP2A instead of PBP2. Because of this modification, penicillin is unable to bind.

Question 3

How did MRSA spread to humans?

Answer 3

From animals

Question 4

What does ESBL stand for? (letters)

Answer 4

Extended spectrum beta lactamase

Question 5

What kind of isolation (normal/strict) do people with MRSA get?

Answer 5

Strict

Question 6

What kind of isolation (normal/strict) do people with ESBL get?

Answer 6

Normal

Question 6

What kind of isolation (normal/strict) do people with ESBL get?

Answer 6

Normal

Question 7

What kind of isolation (normal/strict) do people with Carbapenemases get?

Answer 7

Normal

Question 8

On which food products have ESBLs/Carbapenemases been found? (2)

Answer 8

Raw meat, raw vegetables

Question 9

What is cefiderocol (what antibiotic group)?

Answer 9

Siderophore-cephalosporin

Question 10

How does cefiderocol work? (explain complicated)

Answer 10

The catechol group in a side chain forms a complex with iron and is actively transported into the bacterial cell via a trojan horse mechanism, using the bacterial iron transportation system