Th - Linking the sphingolipid Flashcards
How do amyloid plaques and tau tangles relate to alzheimers? (simple)
They are proteins that are hallmarks for alzheimers, as the disease progresses patients get more and more of them
What are sphingolipids? (simple)
A type of lipid
True or False? Brains with neuroinflammation have more ceramide than healthy brains.
True
What is ceramide? (simple)
A type of sphingolipid
True or False? There is an altered sphingolipid balance in Alzheimer’s.
True
Which kinds of neurological cells produce ceramide?
Astrocytes
What does CerS do?
CerS makes ceramide, it stands for Cermide Synthesis protein
What do Cers2 and Cers5 do? (2)
Cers2 promotes proliferation, Cers5 promotes apoptosis
Which type of CerS do astrocytes make when there is more neuroinflammation, and what kind of consequences does this have?
CerS5, this means that there’s more apoptosis.
Which type of CerS do astrocytes make LESS of when there is more neuroinflammation, and what kind of consequences does this have?
CerS2, this means that there’s less proliferation.
Which balance decides whether or not a cell lives or dies in Alzheimer’s disease and Cerebral Amyloid Angiopathy?
Balance between ceramide and S1P
Which cells produce ceramide in Alzheimer’s Disease? And in which form?
Activated astrocytes
